Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stotz, M; Gerger, A; Haybaeck, J; Kiesslich, T; Bullock, MD; Pichler, M.
Molecular Targeted Therapies in Hepatocellular Carcinoma: Past, Present and Future.
Anticancer Res. 2015; 35(11):5737-5744
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Stotz Michael
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Haybäck Johannes
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Abstract:
- Hepatocellular carcinoma (HCC) is an aggressive tumor and the sixth most common form of cancer worldwide. Surgery is the gold-standard treatment for local disease and often complemented by radiofrequency ablation or transarterial chemoembolization. In advanced disease, therapy options are limited and relapse and metastasis are common. Systemic therapy with cytotoxic drugs such as doxorubicin and cisplatin achieves low objective response rates (typically <10%) and even sorafenib, an orally administered tyrosine kinase inhibitor considered a breakthrough when introduced, prolongs median survival by little more than a year. Sorafenib blocks platelet-derived growth factor, vascular endothelial growth factor, c-KIT and rapidly accelerated fibrosarcoma signaling, and belongs to a new class of targeted drugs. It has become standard treatment for advanced-stage HCC in recent years. To date, no other agent has been shown to be more effective than sorafenib in the clinical setting, which highlights the need for ongoing research to address this important clinical challenge. The current review focuses on recent advances in molecular targeted therapy for HCC. We explore the current status of evidence, identify areas of pressing experimental need, and provide an outline of promising future therapeutic options. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - therapeutic use
- Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism
- Humans -
- Liver Neoplasms - drug therapy Liver Neoplasms - metabolism
- Molecular Targeted Therapy -
- Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism
- Prognosis -
- Find related publications in this database (Keywords)
- Hepatocellular carcinoma
- molecular-targeted therapy
- sorafenib
- tyrosine kinase inhibitor
- review