Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reitz, D; Gerger, A; Seidel, J; Kornprat, P; Samonigg, H; Stotz, M; Szkandera, J; Pichler, M.
Combination of tumour markers CEA and CA19-9 improves the prognostic prediction in patients with pancreatic cancer.
J Clin Pathol. 2015; 68(6):427-433
Doi: 10.1136/jclinpath-2014-202451
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Gerger Armin
- Kornprat Peter
- Samonigg Hellmut
- Seidel Julia
- Stotz Michael
- Szkandera Joanna
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- Abstract:
- Tumour markers including carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA19-9) are frequently determined at the time of diagnosis in patients with pancreatic cancer. Several studies indicate a prognostic relevance of these markers in pancreatic cancer, but space for improvement with regard to the predictive accuracy and ability is given. In this work, the main focus is on mathematical combinations of these two tumour markers in order to validate an improvement of prognostic test results in terms of sensitivity and specificity. This retrospective study includes 393 patients with pancreatic cancer, who were treated between the years 2005 and 2012 at the Division of Oncology, Medical University of Graz, Austria. The goal of this study was to explore whether an appropriate combination of two tumour markers leads to a statistically significant improvement of the prognostic prediction. Receiver operating characteristic curves comparison analyses with the classification variable cancer-specific survival showed that the mathematical product of two tumour markers (TM(product)= (CEA×CA19-9); area under the curve (AUC)=0.727; 95% CI 0.680 to 0.770) is significantly better than CEA alone (AUC=0.644; 95% CI 0.594 to 0.691; p=0.003) but not significant compared with CA19-9 (AUC=0.710; 95% CI 0.662 to 0.754; p=0.1215). A linear combination of CEA and CA19-9 (TM(linear)=(85×CEA+CA19-9); AUC=0.748; 95% CI 0.702 to 0.790) is significantly better than CEA (p<0.0001) as well as CA19-9 alone (p=0.0304). Mathematical combinations of pretherapeutic tumour markers CEA and CA19-9 are feasible and can significantly improve the prognostic prediction in patients with pancreatic cancer. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers, Tumor - metabolism
- CA-19-9 Antigen - metabolism
- Carcinoembryonic Antigen - metabolism
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - mortality
- Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - mortality
- Prognosis -
- ROC Curve -
- Retrospective Studies -