Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bezan, A; Mrsic, E; Krieger, D; Stojakovic, T; Pummer, K; Zigeuner, R; Hutterer, GC; Pichler, M.
The Preoperative AST/ALT (De Ritis) Ratio Represents a Poor Prognostic Factor in a Cohort of Patients with Nonmetastatic Renal Cell Carcinoma.
J Urol. 2015; 194(1):30-35
Doi: 10.1016/j.juro.2015.01.083
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Hutterer Georg
- Terbuch Angelika
- Co-Autor*innen der Med Uni Graz
- Pichler Martin
- Pummer Karl
- Stojakovic Tatjana
- Zigeuner Richard
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- Abstract:
- Aminotransaminases, which are strongly involved in cellular metabolism and cancer cell turnover, represent easily measureable, potential blood based biomarkers. We evaluated the prognostic value of the preoperatively assessed AST/ALT (De Ritis) ratio on clinically meaningful end points in a large European cohort of patients with nonmetastatic renal cell carcinoma. We retrospectively evaluated clinicopathological data on 698 patients with nonmetastatic renal cell carcinoma operated on between 2005 and 2013 at a single tertiary academic center. The potential prognostic value of the AST/ALT ratio was analyzed using the Kaplan-Meier method, and univariate and multivariate Cox proportional regression models. The impact of the ratio on the predictive accuracy of the Leibovich prognosis score was determined by the Harrell c-index. An increased (1.26 or greater) preoperative AST/ALT ratio was statistically significantly associated with several well established prognostic factors, including pathological T stage, as well as with histological tumor necrosis (p <0.05). On multivariate analysis an increased preoperative AST/ALT ratio was an independent prognostic factor for metastasis-free survival (HR 1.61, 95% CI 1.25-2.07, p <0.001) and overall survival (HR 1.76, 95% CI 1.34-2.32, p <0.001). The Harrell c-index was 0.77 using the Leibovich prognosis score and 0.81 when AST/ALT was added. In our study cohort with nonmetastatic renal cell carcinoma the preoperatively assessed AST/ALT ratio represented an independent prognostic factor. This ratio might further improve the predictive accuracy of well established prognosis scores. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alanine Transaminase - blood
- Aspartate Aminotransferases - blood
- Carcinoma, Renal Cell - blood
- Carcinoma, Renal Cell - surgery
- Cohort Studies -
- Female -
- Humans -
- Kidney Neoplasms - blood
- Kidney Neoplasms - surgery
- Male -
- Middle Aged -
- Preoperative Period -
- Prognosis -
- Retrospective Studies -
- Find related publications in this database (Keywords)
- kidney
- carcinoma, renal cell
- transaminases
- prognosis
- biological markers