Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mayr, C; Neureiter, D; Wagner, A; Pichler, M; Kiesslich, T.
The role of polycomb repressive complexes in biliary tract cancer.
Expert Opin Ther Targets. 2015; 19(3):363-375
Doi: 10.1517/14728222.2014.986460
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pichler Martin
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- Abstract:
- Polycomb group proteins are major epigenetic regulators that modify histone tails. They are organized in two multi-protein complexes called polycomb repressive complex (PRC) 1 and 2. Aberrant PRC activity is known to contribute to the development and aggressiveness of many cancers. Biliary tract cancer (BTC) is a rare malignancy associated with high chemoresistance and poor clinical outcome. Here we review the role of the PRC complexes and the effects of RNAi and drug-mediated inhibition of PRC1 and PRC2 in BTC. This review gives a short overview of the composition, biochemical functions and oncogenic role of PRC complexes. We then focus on and summarize the results of current studies that address the role of PRC in BTC. Finally, we discuss options and results of therapeutic targeting of PRC in BTC. Pharmacological inhibition of the two PRC complexes seems to be a promising strategy for treatment of BTC. To date, only few studies have addressed the therapeutic effect of PRC inhibition in BTC. Therefore, it will be important to test established PRC inhibitors, such as DZNep, as well as newly developed drugs, for example, PTC209, to gain more insight into the role of the PRC complexes in BTC and potentially to develop new therapeutic strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - pharmacology
- Biliary Tract Neoplasms - drug therapy
- Biliary Tract Neoplasms - pathology
- Drug Design -
- Drug Resistance, Neoplasm -
- Histones - metabolism
- Humans -
- Molecular Targeted Therapy -
- Polycomb Repressive Complex 1 - antagonists & inhibitors
- Polycomb Repressive Complex 1 - metabolism
- Polycomb Repressive Complex 2 - antagonists & inhibitors
- Polycomb Repressive Complex 2 - metabolism
- RNA Interference -
- Find related publications in this database (Keywords)
- biliary tract cancer
- BMI1
- epigenetics
- EZH2
- histone modifications
- polycomb repressive complex