Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; Zollner-Schwetz, I; Sill, H; Linkesch, W; Lass-Flörl, C; Schnedl, WJ; Krause, R.
Epidemiology of invasive fungal infections and rationale for antifungal therapy in patients with haematological malignancies.
Mycoses. 2011; 54(5):454-459
Doi: 10.1111/j.1439-0507.2010.01881.x
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Krause Robert
- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
- Schnedl Wolfgang
- Sill Heinz
- Zollner-Schwetz Ines
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- Abstract:
- Invasive fungal infections (IFIs) in patients with haematological malignancies are difficult to diagnose and outcome is often fatal. Over the 7-month study period, 117 cases with haematological malignancies receiving systemic antifungal treatment were included. Data regarding antifungal agents, dosage and reason for administration were recorded. Fungal infections in study patients were classified as possible, probable or proven according to recent European Organization for Research and Treatment of Cancer criteria. During the study period, 690 cases with haematological malignancies were admitted. A total of 117 cases received systemic antifungal therapy. Twenty-four of 117 patients (21%) had possible, six (5.1%) had probable and four (3.4%) had proven IFI. Seven of 10 probable and proven infections were caused by Candida spp., 2 by Aspergillus spp. and 1 by a fungus belonging to Zygomycetes. Fifty-two of 117 patients (44%) received antifungal prophylaxis, 81 of 117 (69%) received empirical (31/117; 26%) or pre-emptive (50/117; 43%) antifungal therapy and four of 117 patients (3.4%) directed antifungal therapy. Mostly, systemic antifungal therapy was administered empirically or pre-emptively. Twenty-nine per cent of cases receiving systemic antifungal treatment met the international consensus criteria of mostly possible IFI, whereas 71% did not. Proven invasive fungal infections were rare. © 2010 Blackwell Verlag GmbH.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antifungal Agents - therapeutic use
- Chemoprevention - methods
- Female -
- Fungi - classification
- Fungi - isolation & purification
- Hematologic Neoplasms - complications
- Humans -
- Male -
- Middle Aged -
- Mycoses - drug therapy
- Mycoses - epidemiology
- Prospective Studies -
- Find related publications in this database (Keywords)
- Invasive fungal infection
- antifungal agents
- aspergillosis
- candidiasis
- haematological malignancies