Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Luers, C; Wachter, R; Kleta, S; Uhlir, M; Koschack, J; Scherer, M; Binder, L; Herrmann-Lingen, C; Zapf, A; Kulle, B; Kochen, MM; Pieske, B.
Natriuretic peptides in the detection of preclinical diastolic or systolic dysfunction
CLIN RES CARDIOL. 2010; 99(4): 217-226.
Doi: 10.1007/s00392-009-0108-z
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- The diagnostic value of natriuretic peptides in asymptomatic patients at risk for diastolic or systolic HF is controversial. We tested (1) the prevalence of preclinical LV dysfunction in an at-risk cohort; (2) the diagnostic accuracy of natriuretic peptides alone or in combination with clinical parameters for predicting asymptomatic left ventricular systolic or diastolic dysfunction. 542 primary care patients (mean age 63 +/- A 11 years, 42% female) without prediagnosed HF, but with risk factors for left ventricular dysfunction, underwent thorough cardiological workup, including echocardiography and analysis of natriuretic peptides. 23 patients (4%) showed reduced systolic function (EF < 50%), and 15 patients (3%) had severe diastolic dysfunction. All natriuretic peptides significantly increased with decreasing ejection fraction and with increasing degree of diastolic dysfunction. For natriuretic peptides, receiver operating characteristics analysis yielded good results for the detection of systolic dysfunction or severe diastolic dysfunction. Combining clinical parameters with natriuretic peptide data improved the diagnostic accuracy and largely reduced the number of needed screening echoes to identify patients with LV systolic or diastolic dysfunction. The prevalence of preclinical diastolic dysfunction is high in primary care patients at risk, but the relative prevalence of severe diastolic dysfunction and systolic dysfunction is only 7%. High-risk individuals may be screened most efficiently by using a score system incorporating clinical data and NT-proBNP.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Diastole -
- Echocardiography - methods
- Heart Failure, Diastolic - diagnosis Heart Failure, Diastolic - etiology
- Heart Failure, Systolic - diagnosis Heart Failure, Systolic - etiology
- Humans -
- Mass Screening - methods
- Middle Aged -
- Natriuretic Peptides - metabolism
- Prevalence -
- Primary Health Care - methods
- Prospective Studies -
- Risk Factors -
- Severity of Illness Index -
- Systole -
- Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - epidemiology Ventricular Dysfunction, Left - physiopathology
- Find related publications in this database (Keywords)
- Natriuretic peptides
- Left ventricular function
- Diastolic dysfunction
- Heart failure