Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Brunhuber, T; Haybaeck, J; Schäfer, G; Mikuz, G; Langhoff, E; Saeland, S; Lebecque, S; Romani, N; Obrist, P.
Immunohistochemical tracking of an immune response in mammary Paget's disease.
Cancer Lett. 2008; 272(2): 206-220.
Doi: 10.1016/j.canlet.2008.07.028
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Dendritic cells (DC) are the most potent antigen-presenting cells of the organism. They are specialized to capture, process, and present antigen via the MHC class II as well as the MHC class I pathways to CD4+ and CD8+ T cells, respectively. This results in T cell-mediated immune responses that are likely to counteract the generation and propagation of tumors in vivo. Therefore, we studied the distribution of dendritic cells in mammary Paget's disease. Paraffin-embedded samples of Paget's disease of the breast (n=27) and of disease-free epidermis of the nipple (n=10) were investigated immunohistochemically for the presence of dendritic cells, in particular of Langerhans cells, using antibodies against S-100, CD1a, and HLA-DR, as well as novel reagents against Langerin/CD207, DC-LAMP/CD208 and p55 (Fascin), the latter two being specific for mature dendritic cells. Paget samples presented a decrease of CD1a+, S-100+, and Langerin+ intraepidermal Langerhans cells in almost all cases. This was paralleled by a concentration of immature dendritic cells in the tumor-infiltrated tissue itself. Similar to infiltrating breast carcinoma we observed a marked increase of DC-LAMP+ and p55+ mature dendritic cells in the corial tissue beneath the tumor. These cells were almost always found in ribbon-like or nodular lymphocytic infiltrates. Moreover, rare mature dendritic cells were also found in the Paget cell-infiltrated epidermis of the nipple, i.e. in the tumorous lesion itself. These findings may indicate an effective ongoing anti-tumor immune response in this part of spreading breast cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD - immunology
- Case-Control Studies -
- Dendritic Cells - immunology
- Female -
- Humans -
- Immunohistochemistry -
- Middle Aged -
- Paget's Disease, Mammary - immunology
- Find related publications in this database (Keywords)
- Paget disease
- Immunohistochemistry
- Dendritic cells
- Breast
- Immune response