Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Heikenwalder, M; Federau, C; Boehmer, L; Schwarz, P; Wagner, M; Zeller, N; Haybaeck, J; Prinz, M; Becher, B; Aguzzi, A.
Germinal center B cells are dispensable in prion transport and neuroinvasion.
J Neuroimmunol. 2007; 192(1-2): 113-123. Doi: 10.1016/j.jneuroim.2007.09.022
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Co-Autor*innen der Med Uni Graz: Haybäck Johannes
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Abstract:: Transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases of animals and humans. Many TSEs are initiated by prion replication in the lymphoreticular system (LRS). The cellular and molecular prerequisites for prion trafficking within the LRS are not fully understood. Here we have manipulated CD40 and its ligand to investigate whether genetic or pharmacological ablation of germinal center B cells (GCBs), which migrate into and out of germinal centers, influences prion pathogenesis. In contrast to previous reports, no alteration of prion pathogenesis was detected in mice lacking CD40L and in mice treated with anti-CD40L antibodies. These results suggest that GCBs alone do not impact peripheral splenic prion transport, replication efficiency, or neuroinvasion, and point to other mechanisms affecting prion transport from lymphoreticular sites of replication to the nervous system.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Antibodies - drug effects; B-Lymphocytes - drug effects B-Lymphocytes - physiology; CD40 Ligand - deficiency CD40 Ligand - immunology CD40 Ligand - metabolism; Dendritic Cells, Follicular - drug effects Dendritic Cells, Follicular - physiology; Germinal Center - cytology; Glial Fibrillary Acidic Protein - metabolism; Mice -; Mice, Inbred C57BL -; Mice, Knockout -; PrPSc Proteins - metabolism; Prion Diseases - etiology Prion Diseases - genetics; Prions - genetics Prions - metabolism Prions - pathogenicity; Protein Transport - physiology
Find related publications in this database (Keywords): prions; germinal center B cells (GCBs); follicular dendritic cells (FDCs); prion neuroinvasion; lymphoreticular system (LRS)