Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Logo MUG-Forschungsportal

Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Baumann, CR; Bassetti, CL; Valko, PO; Haybaeck, J; Keller, M; Clark, E; Stocker, R; Tolnay, M; Scammell, TE.
Loss of hypocretin (orexin) neurons with traumatic brain injury.
Ann Neurol. 2009; 66(4): 555-559. Doi: 10.1002/ana.21836 [OPEN ACCESS]
Web of Science PubMed PUBMED Central FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz
Haybäck Johannes
Altmetrics:

Dimensions Citations:

Plum Analytics:

Scite (citation analytics):

Abstract:
Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the hypothalamic neurons that produce the wake-promoting neuropeptide hypocretin (orexin) causes the severe sleepiness of narcolepsy, and partial loss of these cells may contribute to the sleepiness of Parkinson disease and other disorders. We have found that the number of hypocretin neurons is significantly reduced in patients with severe TBI. This observation highlights the often overlooked hypothalamic injury in TBI and provides new insights into the causes of chronic sleepiness in patients with TBI.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Brain Injuries - metabolism Brain Injuries - pathology
Cell Count - methods
Female -
Humans -
Hypothalamus - metabolism Hypothalamus - pathology
Intracellular Signaling Peptides and Proteins - physiology
Male -
Middle Aged -
Neurons - metabolism Neurons - pathology
Neuropeptides - biosynthesis Neuropeptides - physiology
Pilot Projects -
Wakefulness - physiology

© Med Uni Graz Impressum