Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stojakovic, T; de Campo, A; Scharnagl, H; Sourij, H; Schmölzer, I; Wascher, TC; März, W.
Differential effects of fluvastatin alone or in combination with ezetimibe on lipoprotein subfractions in patients at high risk of coronary events.
Eur J Clin Invest. 2010; 40(3): 187-194.
Doi: 10.1111/j.1365-2362.2009.02249.x
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- Führende Autor*innen der Med Uni Graz
- Stojakovic Tatjana
- Co-Autor*innen der Med Uni Graz
- DeCampo Antonella
- März Winfried
- Scharnagl Hubert
- Sourij Harald
- Wascher Thomas
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- Abstract:
- P>Background Ezetimibe, a cholesterol-absorption inhibitor, significantly lowers low-density lipoprotein cholesterol (LDL-C) when administered in addition to statin treatment. The effect of ezetimibe on the incidence and progression of vascular disease is elusive. The objective of the study was to examine the effects of fluvastatin plus ezetimibe on lipoprotein subfractions in patients with type 2 diabetes and/or coronary heart disease. Materials and methods Ninety patients with LDL-C between 100 and 160 mg dL-1 were enrolled in this prospective, randomized, single-blind, single-centre study. A total of 84 patients were treated with either fluvastatin 80 mg (n = 28) alone or in combination with ezetimibe 10 mg (n = 56) for 12 weeks to determine the effects on lipids, apolipoproteins and LDL subfractions by equilibrium density gradient ultracentrifugation. This study is registered with ClinicalTrials.gov, number NCT00814723. Results Total cholesterol, LDL-C and apolipoprotein B were significantly more reduced in the combined therapy group. High density lipoproteins increased in the fluvastatin-only group and decreased in the combined therapy group. There was a significant difference between the two groups in buoyant and intermediate, but not in dense LDL particles. Conclusions Addition of ezetimibe to fluvastatin resulted in a further reduction of buoyant and intermediate, but not of dense LDL compared with fluvastatin alone.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Anticholesteremic Agents - therapeutic use
- Apolipoproteins B - blood
- Azetidines - therapeutic use
- Biological Markers - blood
- Cholesterol - blood
- Coronary Disease - blood
- Diabetes Mellitus, Type 2 - blood
- Drug Therapy, Combination -
- Fatty Acids, Monounsaturated - therapeutic use
- Female -
- Humans -
- Indoles - therapeutic use
- Lipoproteins - blood
- Lipoproteins, LDL - blood
- Male -
- Middle Aged -
- Prospective Studies -
- Find related publications in this database (Keywords)
- Atherogenic lipoprotein phenotype
- coronary heart disease
- ezetimibe
- fluvastatin
- lipopoprotein subfractions
- type 2 diabetes