Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wilders-Truschnig, M; Mangge, H; Lieners, C; Gruber, HJ; Mayer, C; März, W.
IgG antibodies against food antigens are correlated with inflammation and intima media thickness in obese juveniles.
Exp Clin Endocrinol Diabetes. 2008; 116(4):241-245
Doi: 10.1055/s-2007-993165
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- Führende Autor*innen der Med Uni Graz
- Truschnig-Wilders Martini
- Co-Autor*innen der Med Uni Graz
- Bernecker Claudia
- Gruber Hans-Jürgen
- Mangge Harald
- März Winfried
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- Abstract:
- Objective: Systemic low grade inflammation may contribute to the development of obesity, insulin resistance, diabetes mellitus and atherosclerotic vascular disease. Food intolerance reflected by immunoglobulin G (IgG) antibodies may predispose to low grade inflammation and atherogenesis. We examined the relationship between IgG antibodies specific for food components, low grade inflammation and early atherosclerotic lesions in obese and normal weight juveniles. Research Methods and Procedures: We determined IgG antibodies directed against food antigens, C-reactive protein (CRP) and the thickness of the intima media layer (IMT) of the carotid arteries in 30 obese children and in 30 normal weight children. Results: Obese juveniles showed a highly significant increase in IMT (p=0.0001), elevated CRIP values (p=0.0001) and anti-food IgG antibody concentrations (p=0.0001) compared to normal weight juveniles. Anti-food IgG showed tight correlations with CRP (p=0.001/r=0.546) and IMT (p=0.0001/r=0.513) and sustained highly significant in a multiple regression model. Discussion: We show here, that obese children have significantly higher IgG antibody values directed against food antigens than normal weight children. Anti- food IgG antibodies are tightly associated with low grade systemic inflammation and with the IMT of the common carotid arteries. These findings raise the possibility, that anti-food IgG is pathogenetically involved in the development of obesity and atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antigens -
- Blood Pressure -
- C-Reactive Protein - metabolism
- Child -
- Food Hypersensitivity - blood Food Hypersensitivity - immunology
- Humans -
- Immunoglobulin G - blood
- Inflammation - blood Inflammation - immunology Inflammation - pathology
- Obesity - blood Obesity - immunology Obesity - pathology
- Reference Values -
- Tunica Intima - pathology
- Tunica Media - pathology
- Find related publications in this database (Keywords)
- coronary artery
- cardiovascular incidences
- oxidative