Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Seewann, A; Enzinger, C; Filippi, M; Barkhof, F; Rovira, A; Gass, A; Miller, D; Montalban, X; Thompson, A; Yousry, T; Tintore, M; de Stefano, N; Palace, J; Rovaris, M; Polman, C; Fazekas, F; for the MAGNIMS network.
MRI characteristics of atypical idiopathic inflammatory demyelinating lesions of the brain : A review of reported findings.
J Neurol. 2008; 255(1): 1-10.
Doi: 10.1007/s00415-007-0754-x
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- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Seewann Alexandra
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
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- Abstract:
- BACKGROUND : Idiopathic inflammatory demyelinating lesions (IIDL) of the brain usually present with a morphologic pattern characteristic of multiple sclerosis (MS). Atypical appearances of IIDLs also exist, however, and can pose significant diagnostic problems and uncertainty regarding prognosis and adequate therapy. We attempted to improve upon this situation by reviewing the literature. METHODS : We performed a PubMed search from January 1984 through December 2004 for articles in English reporting on IIDLs which had been considered as morphologically atypical (66 articles; 270 cases reported). From these publications 69 individual patient reports allowed the extraction of adequate information on magnetic resonance imaging (MRI) and associated disease characteristics. RESULTS : Reported atypical IIDLs most frequently manifested as large ring-like lesions (n = 27) which are now considered quite suggestive of an antibodymediated form of MS. Truly atypical IIDLs were less common and exhibited appearances which we termed megacystic (n = 8), Balolike (n = 11) and diffusely infiltrating (n = 11). Despite limitations imposed by the absence of original data the inter-rater agreement in defining these subtypes of atypical IIDLs was moderate to substantial (kappa 0.48-0.68) and we noted trends for their association with certain demographic, clinical and paraclinical variables. INTERPRETATION : We suggest that IIDLs reported as atypical in the literature can be segregated into several distinct subtypes based on their MRI appearance. The recognition of these patterns may be useful for the differential diagnosis and for a future classification. Because of the limitations inherent in our review this will have to be confirmed by a prospective registry.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Brain - pathology
- Cerebrum - pathology
- Demyelinating Diseases - classification
- Diagnosis, Differential -
- Encephalitis - classification
- Female -
- Humans -
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Multiple Sclerosis - pathology
- Nerve Fibers, Myelinated - pathology
- Observer Variation -
- Predictive Value of Tests -
- Find related publications in this database (Keywords)
- magnetic resonance imaging
- idiopathic inflammatory demyelinating disorders
- atypical multiple sclerosis