Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Neumann, T; Esser, S; Potthoff, A; Pankuweit, S; Neumann, A; Breuckmann, F; Neuhaus, K; Kondratieva, J; Buck, T; Müller-Tasch, T; Wachter, R; Prettin, C; Gelbrich, G; Herzog, W; Pieske, B; Rauchhaus, M; Löffler, M; Maisch, B; Mügge, A; Wasem, J; Gerken, G; Brockmeyer, NH; Erbel, R; HIV-HEART Study Investigative Group.
Prevalence and natural history of heart failure in outpatient HIV-infected subjects: rationale and design of the HIV-HEART study.
Eur J Med Res. 2007; 12(6):243-248
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Background: HIV infection is a global public health issue that is frequently associated with cardiac involvement. However, myocardial dysfunction and heart failure are often clinically occult or attributed incorrectly to other non-cardiac disease processes even a heightened awareness and knowledge for these cardiac diseases in HIV-infected patients may lead to earlier detection and a reduction in morbidity and mortality The present study evaluates the frequency and clinical course of Myocardial dysfunction and heart failure in a HIV-infected population. Methods: The HIV-HEART (HIV-infection and HEART disease) study is a prospective, long-term cohort study The study is designed and powered to define prevalence and natural history of chronic heart failure. Following a pilot-study of 105 HIV-infected subjects the HIV-HEART trial will contain 802 HIV-infected males and females with and without antiretroviral therapy in an urban population. HIV-HEART is performed by using non-invasive techniques for the quantification of exercise intolerance and ventricular dysfunction, including concentration of B-type natriretic peptide (BNP), transthoracal echocardiography and endurance testing. Patients with BNP >100 pg/ml achieve a magnetic resonance tomography of the heart for characterization of myocardial dysfunction and type of cardiomyopathy. To determine incidence and natural history of myocardial dysfunction and heart failure, a 2 year follow-up started in September 2006. Conclusions: The HIV-HEART study will define the significance of myocardial dysfunction and heart failure in a HIV-infected urban population and classify appropriate methods for identifying high-risk patients, the basis for risk stratification and therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Pressure Determination -
- Cardiac Output, Low - diagnosis Cardiac Output, Low - epidemiology
- Echocardiography -
- Electrocardiography -
- Female -
- HIV Infections - complications
- Humans -
- Male -
- Prevalence -
- Find related publications in this database (Keywords)
- human immunodeficiency virus
- antiretroviral therapy
- heart failure
- myocardial dysfunction