Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Binder, A; Endler, G; Müller, M; Mannhalter, C; Zenz, W; European Meningococcal Study Group.
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia.
J Thromb Haemost. 2007; 5(10):2049-2054
Doi: 10.1111/j.1538-7836.2007.02724.x
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- Führende Autor*innen der Med Uni Graz
- Binder Alexander
- Zenz Werner
- Co-Autor*innen der Med Uni Graz
- Müller Martin
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- Abstract:
- Meningococcal disease may present as sepsis, meningitis or a combination of both. Impaired fibrinolysis and massive elevation of the plasminogen activator inhibitor-1 (PAI-1) is a characteristic feature of meningococcal sepsis. We and others have reported an association between mortality and the functional 4G/5G promoter polymorphism of the PAI-1 gene in children with meningococcal sepsis. Multicenter study to investigate the association of the 4G/5G PAI-1 polymorphism and disseminated intravascular coagulation (DIC) in children with meningococcal disease in a Central European population. Blood samples and clinical information of 326 previously healthy children with meningococcal infection were collected from 95 pediatric hospitals in Germany, Switzerland, Italy, and Austria from 2000 to 2002. DIC, defined as platelet counts below 100 G L(-1), increased D-dimer levels and prolonged prothrombin time, was significantly associated with the 4G4G genotype [31 of 63 (49%) vs. 55 of 175 (31%), P = 0.014], resulting in a hazard ratio (HR) of 1.5 (95% confidence interval 1.1-2.1) to develop DIC. Carriers of the 4G4G genotype showed significantly lower platelet counts (183 G L(-1) vs. 227 G L(-1), P = 0.009) on admission. Fibrinogen and C-reactive protein levels were not associated with the PAI-1 4G/5G polymorphism, nor were white blood cell counts. Our data show a correlation between the 4G4G genotype of the PAI-1 gene and development of DIC in meningococcal infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- C-Reactive Protein - metabolism
- Child -
- Child, Preschool -
- Disseminated Intravascular Coagulation - blood
- Disseminated Intravascular Coagulation - complications
- Disseminated Intravascular Coagulation - genetics
- Female -
- Fibrinogen - genetics
- Fibrinogen - metabolism
- Genotype -
- Humans -
- Infant -
- Infant, Newborn -
- Male -
- Meningococcal Infections - complications
- Meningococcal Infections - genetics
- Plasminogen Activator Inhibitor 1 - genetics
- Polymorphism, Genetic -
- Promoter Regions, Genetic -
- Find related publications in this database (Keywords)
- disseminated intravascular coagulation
- fibrinogen
- meningococcal disease
- PAI-1
- platelet count
- polymorphism