Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langner, C; Ratschek, M; Rehak, P; Schips, L; Zigeuner, R.
Are heterogenous results of EGFR immunoreactivity in renal cell carcinoma related to non-standardised criteria for staining evaluation?
J CLIN PATHOL. 2004; 57(7): 773-775.
Doi: 10.1136/jcp.2003.015743
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Ratschek Manfred
- Rehak Peter
- Schips Luigi
- Zigeuner Richard
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- Abstract:
- AIMS: To assess whether heterogeneity of epidermal growth factor receptor (EGFR) immunoreactivity in renal cell carcinoma (RCC) is related to non-standardised criteria for staining evaluation. METHODS: EGFR expression was investigated in 132 primary and 55 metastatic conventional RCCs using a tissue microarray technique. RESULTS: Overall, membranous and/or cytoplasmic EGFR immunostaining was present in 123 of 132 (93%) primary and 49 of 53 (92%) metastatic RCCs, with extensive immunoreactivity (> 50% of tumour cells) in 110 of 132 (83%) primary tumours and 39 of 53 (73%) metastases. Cytoplasmic staining was associated with high tumour stage and high tumour grade. In addition, strong membranous staining (score 3+) prevailed in high grade RCCs. Cytoplasmic immunostaining was associated with an unfavourable prognosis, whereas overall (cytoplasmic and membranous) immunoreactivity and intensity of membranous staining were not. CONCLUSIONS: Different methods of immunohistochemical evaluation led to different results, strengthening the need for standardisation, especially against a background of rapidly evolving EGFR targeted cancer treatment strategies.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Renal Cell - chemistry
- Cell Membrane - chemistry
- Cytoplasm - chemistry
- Humans - chemistry
- Kidney Neoplasms - chemistry
- Neoplasm Staging - chemistry
- Prognosis - chemistry
- Protein Array Analysis - methods
- Reagent Kits, Diagnostic - standards
- Receptor, Epidermal Growth Factor - analysis
- Reproducibility of Results - analysis
- Tumor Markers, Biological - analysis