Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, A; Raggam, RB; Stammberger, H; Beham, A; Braun, H; Kleinhappl, B; Buzina, W; Kittinger, C; Reinisch, S; Berghold, A; Freudenschuss, K; Barth, S; Marth, E.
The role of interleukin-16 in eosinophilic chronic rhinosinusitis.
Eur Arch Otorhinolaryngol. 2007; 264(8): 887-893.
Doi: 10.1007/s00405-007-0300-6
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- Führende Autor*innen der Med Uni Graz
- Lackner Andreas
- Co-Autor*innen der Med Uni Graz
- Barth Sonja
- Beham Alfred
- Berghold Andrea
- Braun Hannes
- Buzina Walter
- Freudenschuss Kurt
- Kittinger Clemens
- Kleinhappl Barbara
- Marth Egon
- Raggam Reinhard Bernd
- Reinisch Sabine
- Stammberger Heinz
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- Abstract:
- Eosinophilic granulocytes (Eos) are found in great numbers both in the tissue and in the mucus of patients suffering from chronic rhinosinusitis with polyposis (ECRS). Interleukin-16 (IL-16) is known as a highly potent chemotactic and chemoattractant molecule (ED 10-11) for Eos. In an open, explorative, controlled study we examined the presence of IL-16 in mucosa tissue, mucus and serum in patients suffering from ECRS and its association to Eos activation. Tissue and nasal mucus specimen from 10 previously untreated, non allergic ECRS-patients undergoing paranasal sinus surgery and from 10 healthy non sinusitis subjects, undergoing nasal surgery because of anatomic nasal obstruction were investigated by real-time (RT-) PCR targeting human IL-16 mRNA. Haematoxylin-eosin (HE) staining and immunohistochemistry of formalin embedded tissue and mucus were applied for detection and determination of the proportion of activated Eos (aEos) and IL-16. Serum IL-16 was analyzed by enzyme-linked-immunosorbent assay (ELISA). IL-16 mRNA and IL-16 protein levels were elevated in nasal mucus, polyp tissue and in the serum of ECRS patients compared to healthy controls. There was a high proportion of aEos in ECRS patients compared to healthy subjects. Serum IL-16, IL-16 mRNA expression and IL-16 protein in mucus and tissue specimens were significantly associated with the presence of aEos in polyps of ECRS patients. Immunohistochemically IL-16 protein was mainly expressed in aEos, mast cells, lymphocytes and epithelial cells. In conclusion our data indicate that IL-16 may stimulate the migration and persistence of activated Eos in ECRS. IL-16 production in ECRS patients is not mediated by Immunglobuline-E (IgE).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies, Anti-Idiotypic - immunology
- Biological Markers - metabolism
- Chronic Disease - metabolism
- Enzyme-Linked Immunosorbent Assay - metabolism
- Eosinophilia - complications
- Eosinophils - metabolism
- Female - metabolism
- Gene Expression - metabolism
- Humans - metabolism
- Immunoglobulin E - immunology
- Immunohistochemistry - immunology
- Interleukin-6 - genetics
- Male - genetics
- Middle Aged - genetics
- Nasal Mucosa - immunology
- Polymerase Chain Reaction - immunology
- RNA, Messenger - genetics
- Rhinitis - complications
- Severity of Illness Index - complications
- Find related publications in this database (Keywords)
- chronic rhinosinusitis
- eosinophils
- IL-16