Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ahrendt, HJ; Nisand, I; Bastianelli, C; Gómez, MA; Gemzell-Danielsson, K; Urdl, W; Karskov, B; Oeyen, L; Bitzer, J; Page, G; Milsom, I.
Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 microg of ethinyl estradiol and 3 mg of drospirenone.
Contraception. 2006; 74(6):451-457
Doi: 10.1016/j.contraception.2006.07.004
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Urdl Wolfgang
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- Abstract:
- PURPOSE: This randomized multicenter, open-label, trial compared efficacy, acceptability, tolerability and compliance of NuvaRing with a combined oral contraceptive (COC), containing 30 microg of ethinyl estradiol (EE) and 3 mg of drospirenone. METHOD: In this 13-cycle study, 983 women were randomized and treated (intent-to-treat population) with NuvaRing or COC. RESULTS: One in-treatment pregnancy occurred with NuvaRing (Pearl Index=0.25) (95% confidence interval [CI]: 0.006, 1.363) and four with the COC (Pearl Index=0.99) (95% CI: 0.269, 2.530). For both groups, compliance (89.2% NuvaRing, 85.5% COC) and satisfaction (84% NuvaRing; 87% COC) were high; the vast majority of women found NuvaRing easy to insert (96%) and remove (97%). Tolerability was similar; the most frequent adverse events with NuvaRing were related to ring use, whereas estrogen-related events were more common with the COC. CONCLUSION: NuvaRing has comparable efficacy and tolerability to a COC containing 30 microg of EE and 3 mg drospirenone. User acceptability of both methods was high.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Androstenes - administration and dosage
- Contraception - administration and dosage
- Contraceptive Agents - administration and dosage
- Contraceptives, Oral, Combined - administration and dosage
- Desogestrel - administration and dosage
- Drug Combinations - administration and dosage
- Ethinyl Estradiol - administration and dosage
- Female - administration and dosage
- Humans - administration and dosage
- Intrauterine Devices - adverse effects
- Patient Compliance - adverse effects
- Patient Satisfaction - adverse effects
- Pregnancy - adverse effects
- Progesterone Congeners - administration and dosage
- Treatment Outcome - administration and dosage
- Find related publications in this database (Keywords)
- NuvaRing
- contraceptive
- compliance
- efficacy
- tolerability
- pill