Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mangge, H; Hubmann, H; Pilz, S; Schauenstein, K; Renner, W; März, W.
Beyond cholesterol--inflammatory cytokines, the key mediators in atherosclerosis.
Clin Chem Lab Med. 2004; 42(5):467-474
Doi: 10.1515/CCLM.2004.081
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- Hubmann Holger
- März Winfried
- Renner Wilfried
- Schauenstein Konrad
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- Abstract:
- The development of atherosclerotic lesions encompasses a cascade of cellular and molecular responses that can at best be characterized as an inflammatory process, and exhibits striking similarities to autoimmune diseases, such as rheumatoid arthritis. Chemokines, cytokines and their receptors are critically involved in initiation and perpetuation of atherosclerosis, and they play important roles at all levels in the pathogenesis of this disease. In the present article, the currently available information on cytokines and chemokines as key mediators in atherosclerosis is reviewed. Furthermore, based on recent experiences of our own with very early stages of atherosclerosis, possible new ways to make use of these parameters toward improved early detection, prevention and treatment of this disease are indicated.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arteriosclerosis - immunology Arteriosclerosis - metabolism Arteriosclerosis - physiopathology
- Autoimmune Diseases - complications Autoimmune Diseases - metabolism Autoimmune Diseases - physiopathology
- Cardiovascular System - immunology Cardiovascular System - physiopathology
- Cell Adhesion Molecules - metabolism
- Cholesterol - metabolism
- Cytokines - immunology Cytokines - metabolism
- Endothelial Cells - immunology Endothelial Cells - metabolism
- Humans -
- Infection - complications Infection - immunology Infection - metabolism
- Inflammation - complications Inflammation - immunology Inflammation - metabolism
- Inflammation Mediators - immunology Inflammation Mediators - metabolism
- Lipid Metabolism -
- Models, Immunological -
- T-Lymphocytes - immunology T-Lymphocytes - metabolism
- Find related publications in this database (Keywords)
- atherosclerosis
- immune-mediated inflammation
- inflammatory biomarkers