Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fruhwald, S; Herk, E; Schöll, G; Shahbazian, A; Hammer, HF; Metzler, H; Holzer, P.
Endotoxin pretreatment modifies peristalsis and attenuates the antipropulsive action of adrenoceptor agonists in the guinea-pig small intestine.
Neurogastroenterol Motil. 2004; 16(2):213-222
Doi: 10.1111/j.1365-2982.2004.00509.x
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- Führende Autor*innen der Med Uni Graz
- Fruhwald Sonja
- Holzer Peter
- Co-Autor*innen der Med Uni Graz
- Hammer Heinz
- Metzler Helfried
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- Abstract:
- The action of endotoxin to alter gastrointestinal motility in vivo may reflect a direct effect on the gut or result from vascular and other systemic manifestations of this sepsis model. Here we examined whether in vivo pretreatment of guinea-pigs with endotoxin modifies peristalsis in the isolated gut and influences the antipropulsive action of adrenoceptor agonists. Distension-induced peristalsis was recorded in fluid-perfused segments of the small intestine taken from animals pretreated intraperitoneally with endotoxin (1 mg kg(-1)Escherichia coli lipopolysaccharide) or vehicle 4 or 20 h before. Clonidine, adrenaline, noradrenaline, dopamine and dobutamine inhibited peristalsis with differential potency. Endotoxin pretreatment lowered the peristaltic pressure threshold and altered other parameters of baseline peristalsis in a time-related manner. The potency and efficacy of clonidine to inhibit peristalsis were markedly decreased after endotoxin administration, while the potency of the other test drugs was less attenuated. The antipropulsive action of clonidine in control segments was reduced by yohimbine and prazosin, whereas in segments from endotoxin-pretreated animals it was antagonized by yohimbine but not prazosin. We conclude that systemic endotoxin pretreatment of guinea-pigs modifies baseline peristalsis by an action on the gut and inhibits the antipropulsive action of adrenoceptor agonists through changes in adrenoceptor activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic Agonists - pharmacology
- Animals - pharmacology
- Endotoxins - pharmacology
- Female - pharmacology
- Guinea Pigs - pharmacology
- Intestine, Small - drug effects
- Male - drug effects
- Muscle, Smooth - drug effects
- Organ Culture Techniques - drug effects
- Peristalsis - drug effects
- Receptors, Adrenergic - drug effects
- Find related publications in this database (Keywords)
- adrenoceptor agonists
- bacterial endotoxin
- catecholamines
- clonidine
- intestinal peristalsis
- sepsis