Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krumnikl, JJ; Toller, WG; Prenner, G; Metzler, H.
Beneficial outcome after prostaglandin-induced post-partum cardiac arrest using levosimendan and extracorporeal membrane oxygenation.
ACTA ANAESTHESIOL SCAND. 2006; 50(6): 768-770.
Doi: 10.1111/j.1399-6576.2006.01034.x
(- Case Report)
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Krumnikl Jakub
- Co-Autor*innen der Med Uni Graz
- Metzler Helfried
- Prenner Günther
- Toller Wolfgang
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- Abstract:
- BACKGROUND: Administration of high doses of prostaglandins is a frequently performed and effective method for the treatment of atonic uterine haemorrhage in order to increase uterine muscle tone. Rarely, however, these drugs may cause life-threatening complications including bronchospasm, acute pulmonary oedema and myocardial infarction caused by coronary spasms. METHODS: We discuss the management of a patient suffering post-partum atonic uterine bleeding, catecholamine-resistant cardiac arrest and fulminant pulmonary failure due to deleterious side-effects of treatment with prostaglandins. RESULTS: During therapy resistant cardiopulmonary resuscitation, the addition of levosimendan to standard medications resulted in a prompt stabilization of haemodynamics. Subsequent treatment of pulmonary failure was successfully managed with ECMO. CONCLUSION: Although levosimendan is not approved for pharmacological treatment of cardiopulmonary arrest, the beneficial effects in this patient suggest an important role of calcium sensitization and vasodilation during prostaglandin-induced cardiac arrest.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cardiotonic Agents - therapeutic use
- Catecholamines - therapeutic use
- Cesarean Section - therapeutic use
- Drug Resistance - therapeutic use
- Extracorporeal Membrane Oxygenation - therapeutic use
- Female - therapeutic use
- Heart Arrest - chemically induced
- Hemodynamics - drug effects
- Humans - drug effects
- Hydrazones - therapeutic use
- Lung Diseases - complications
- Postpartum Hemorrhage - drug therapy
- Pregnancy - drug therapy
- Prostaglandins - adverse effects
- Pyridazines - therapeutic use
- Treatment Outcome - therapeutic use
- Uterine Diseases - drug therapy
- Find related publications in this database (Keywords)
- catecholamine
- epinephrine
- levosimendan
- extracorporeal membrane oxygenation
- resuscitation
- prostaglandins
- atonic uterine hemorrhage