Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Langner, C; Wegscheider, BJ; Ratschek, M; Schips, L; Zigeuner, R.
Keratin immunohistochemistry in renal cell carcinoma subtypes and renal oncocytomas: a systematic analysis of 233 tumors.
VIRCHOWS ARCHIV. 2004; 444(2): 127-134.
Doi: 10.1007/s00428-003-0948-2
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- Führende Autor*innen der Med Uni Graz
- Langner Cord
- Co-Autor*innen der Med Uni Graz
- Langner-Wegscheider Beate Julia
- Ratschek Manfred
- Schips Luigi
- Zigeuner Richard
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- Abstract:
- Keratin immunohistochemistry represents a widely applied differential diagnostic tool in surgical pathology. To investigate the value of keratin subtyping for the diagnosis among histological subtypes of renal cell carcinoma and oncocytomas, we performed a detailed immunohistochemical study, applying 22 different monoclonal keratin antibodies on a large series of 233 renal tumors [125 conventional, 22 chromophobe, and 20 papillary (12 type-1, 8 type-2 tumors) cancers and 66 oncocytomas] using a tissue microarray technique. Immunoreactivity for keratin 7, 8, 18, and 19 was present in all tumor entities, albeit in varying quantities. With antibodies directed against keratins 8 and 18, oncocytomas showed a distinct perinuclear and punctate dot-like pattern, which was not observed in renal cancer specimens. The only tumors showing immunoreactivity for keratin 20 were two type-2 papillary cancers. All other monospecific keratin antibodies yielded consistently negative results. Overall, in contrast to some recent publications, keratin subtyping generally appeared to be of additional value only for the differentiation of renal epithelial tumors. Hence, with respect to differential diagnostic value, Hale's colloidal iron stain and vimentin immunostaining are still the most useful tools in renal tumor pathology.
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- Adenoma, Oxyphilic - diagnosis
- Adult - diagnosis
- Aged - diagnosis
- Aged, 80 and over - diagnosis
- Carcinoma, Renal Cell - diagnosis
- Diagnosis, Differential - diagnosis
- Female - diagnosis
- Humans - diagnosis
- Immunohistochemistry - diagnosis
- Keratins - metabolism
- Kidney Neoplasms - diagnosis
- Male - diagnosis
- Middle Aged - diagnosis
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- renal cell carcinoma
- oncocytoma
- histological subtype
- keratin
- differential diagnosis