Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sipurzynski-Budrass, S; Macher, S; Haeusler, M; Lanzer, G.
Successful treatment of premature rupture of membranes after genetic amniocentesis by intra-amniotic injection of platelets and cryoprecipitate (amniopatch): a case report.
VOX SANG. 2006; 91(1): 88-90.
Doi: 10.1111/j.1423-0410.2006.00784.x
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Sipurzynski Sabine
- Co-Autor*innen der Med Uni Graz
- Haeusler Martin
- Lanzer Gerhard
- Macher Susanne
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- Abstract:
- Background and Objectives Iatrogenic premature rupture of membranes (PROM) occurs in approximately 1% of patients after genetic amniocentesis. If membranes do not seal spontaneously, fluid leakage through the vagina may cause infection and pregnancy loss. Intra-amniotic infusion of a platelet concentrate followed by a cryoprecipitate (amniopatch) is a possible therapeutic approach to restore the amnio-corial link and to facilitate the amniotic repair process. Materials and Methods The autologeous platelet concentrate was produced by apheresis (MCS+, Haemonetics) and contained a total amount of 48 x 10(9) platelets in a volume of 30 ml. The concentration of fibrinogen in our cryoprecipitate (20 ml) was 680 mg/dl. An amniocentesis was performed to apply the amniopatch. The platelet concentrate was administered first followed by the cryoprecipitate. Results We report the successful treatment of a 38-year-old woman with ruptured membranes after genetic amniocentesis in the 16th gestational week. Ten days after placement of the amniopatch we found a complete closure of the rupture, and in the 36th week of gestation the patient delivered a healthy infant by Caesarean section. Conclusions Intra-amniotic injection of platelets and cryoprecipitate was a successful and safe therapy for PROM in this patient. Knowledge of the site of rupture is not necessary for the amniopatch, as platelets seem to find their way to the defect and seal it. We consider that amniopatch therapy for iatrogenic PROM is a possible therapeutic alternative for prolonging and preserving pregnancy and improving the fetal outcome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Amniocentesis - adverse effects
- Amnion - injuries
- Blood Transfusion, Intrauterine -
- Factor VIII - administration and dosage
- Female -
- Fetal Membranes, Premature Rupture - etiology Fetal Membranes, Premature Rupture - therapy
- Fibrinogen - administration and dosage
- Humans -
- Injections -
- Platelet Transfusion -
- Pregnancy -
- Pregnancy Trimester, Second -
- Find related publications in this database (Keywords)
- amniopatch
- genetic amniocentesis
- iatrogenic PROM
- intra-amniotic infusion