Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eibl, M; Auner, HW; Zinke-Cerwenka, W; Sill, H; Dornbusch, HJ; Linkesch, W.
High-risk AML complicated by pulmonary aspergillosis: successful treatment with nonmyeloablative stem cell transplantation and long-term administration of voriconazole.
ANN HEMATOL. 2004; 83(2): 133-136.
Doi: 10.1007/s00277-003-0782-2
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Eibl Margit
- Co-Autor*innen der Med Uni Graz
- Dornbusch Hans Jürgen
- Linkesch Werner
- Sill Heinz
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- Abstract:
- Acute myeloid leukemia (AML) associated with central diabetes insipidus (DI) and chromosomal aberrations is characterised by a very poor prognosis. We present a 28-year-old female with AML FAB M0, preceding DI and cytogenetic abnormalities (monosomy 7 and inversion of chromosome 9). Complete remission was achieved with FLAG after she was refractory to two different induction regimens. Prolonged neutropenia resulted in invasive pulmonary aspergillosis. Allogeneic stem cell transplantation from a matched unrelated donor was performed using a reduced-intensity conditioning regimen. Desmopressin substitution for DI was withdrawn after transplant without recurrence of symptoms. Initial antifungal treatment, including liposomal amphotericin B, caspofungin and itraconazole, was replaced by voriconazole after deterioration of pulmonary aspergillosis, resulting in improvement, stabilisation and finally, also as the combined effect of discontinuation of the immunosuppressive therapy, in disappearance of signs and symptoms. Thirteen months after transplant, the patient is in continuous complete remission. The presented case study thus demonstrates that high-risk AML with concomitant invasive fungal infection may be safely and effectively treated by nonmyeloablative stem cell transplantation and long-term administration of voriconazole.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antifungal Agents - administration and dosage
- Aspergillosis - complications
- Female - complications
- Humans - complications
- Leukemia, Myelocytic, Acute - microbiology
- Lung Diseases, Fungal - drug therapy
- Myeloablative Agonists - therapeutic use
- Pyrimidines - administration and dosage
- Radiography, Thoracic - administration and dosage
- Stem Cell Transplantation - administration and dosage
- Tomography, X-Ray Computed - administration and dosage
- Transplantation Conditioning - methods
- Triazoles - administration and dosage
- Find related publications in this database (Keywords)
- AML
- diabetes insipidus
- aspergillosis
- voriconazole
- nonmyeloablative stem cell transplantation