Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Endler, G; Marculescu, R; Starkl, P; Binder, A; Geishofer, G; Müller, M; Zöhrer, B; Resch, B; Zenz, W; Mannhalter, C; Central European Meningococcal Genetic Study Group.
Polymorphisms in the interleukin-1 gene cluster in children and young adults with systemic meningococcemia.
Clin Chem. 2006; 52(3):511-514
Doi: 10.1373/clinchem.2005.058537
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- Co-Autor*innen der Med Uni Graz
- Binder Alexander
- Müller Martin
- Resch Bernhard
- Zenz Werner
- Zöhrer Bettina
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- Abstract:
- An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-511)C/T, IL1B (-31)C/T, IL1B (+3954), and IL1RA (+2018)C/T. We studied the same polymorphisms in a comparison group of 481 healthy newborns. Genotype frequencies between patients and the comparison group differed significantly only for the IL1RA (+2018)C/T variant: The CC genotype was more frequent in patients (11%) than in healthy controls (5%; P = 0.008). In the patient group, the C allele was significantly more prevalent (67%) in nonsurvivors than in survivors (42%; P = 0.02). The IL1RA (+2018)C/T polymorphism is associated with the risk of meningococcal disease and with its outcome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Child -
- Child, Preschool -
- Child, Preschool -
- European Continental Ancestry Group -
- Female -
- Gene Frequency -
- Genetic Predisposition to Disease -
- Genotype -
- Humans -
- Infant -
- Infant, Newborn -
- Interleukin-1 - genetics
- Male -
- Meningococcal Infections - genetics
- Meningococcal Infections - immunology
- Multigene Family -
- Polymorphism, Genetic -