Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Faber, J; Meyer, CU; Gemmer, C; Russo, A; Finn, A; Murdoch, C; Zenz, W; Mannhalter, C; Zabel, BU; Schmitt, HJ; Habermehl, P; Zepp, F; Knuf, M.
Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy.
PEDIAT INF DIS J. 2006; 25(1): 80-81.
Doi: 10.1097/01.inf.0000195595.22547.fe
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- Co-Autor*innen der Med Uni Graz
- Zenz Werner
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- Abstract:
- Toll-like receptor 4 (TLR4) is required for efficient recognition of bacterial infections. We investigated an association between 2 TLR4 mutations (Asp(299)Gly and Thr(399)Ile) and meningococcal disease in 197 patients and 214 healthy controls by allele-specific real time polymerase chain reaction and direct sequencing. Although the allele frequency was not higher in the overall patient population, a significantly higher frequency in the 40 patients younger than 12 months of age (P = 0.007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Alleles -
- Amino Acid Substitution -
- Child -
- Child, Preschool -
- DNA - chemistry
- Europe - chemistry
- Female - chemistry
- Gene Frequency - chemistry
- Genetic Predisposition to Disease - chemistry
- Humans - chemistry
- Infant - chemistry
- Male - chemistry
- Meningococcal Infections - genetics
- Mutation, Missense - genetics
- Polymerase Chain Reaction - genetics
- Sequence Analysis, DNA - genetics
- Toll-Like Receptor 4 - genetics
- Find related publications in this database (Keywords)
- innate immunity
- Toll-like receptor
- meningococcal disease