Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kapeller, P; Ropele, S; Enzinger, C; Lahousen, T; Strasser-Fuchs, S; Schmidt, R; Fazekas, F.
Discrimination of white matter lesions and multiple sclerosis plaques by short echo quantitative 1H-magnetic resonance spectroscopy.
J NEUROL. 2005; 252(10): 1229-1234.
Doi: 10.1007/s00415-005-0847-3
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- Führende Autor*innen der Med Uni Graz
- Kapeller Peter
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Fuchs Siegrid
- Lahousen-Luxenberger Theresa
- Ropele Stefan
- Schmidt Reinhold
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- Abstract:
- Multiple sclerosis (MS) plaques and age related white matter lesions (WML) are of similar morphological appearance on T2 weighted MRI. Therefore their differentiation is sometimes crucial. Proton magnetic resonance spectroscopy ((1)H-MRS) adds metabolic information to conventional imaging and may help to distinguish inflammatory MS plaques from vascular related WML. This study was performed to evaluate the metabolite pattern in MS plaques and WML. 15 MS patients, 14 elderly individuals with WML and 16 controls were investigated by conventional MRI and short echo quantitative (1)H-MRS (TE: 30ms, TR: 3000ms). The mean metabolite concentrations in normal control white matter (NCWM), MS plaques and WML were: t-NAA: 8.96 mmol/l (SD: 0.93) vs 6.79 mmol/l (SD: 1.99) vs 7.18 mmol/l (SD: 1.41); Cho:1.66 mmol/l (SD: 0.4) vs 1.49 mmol/l (SD: 0.45) vs 1.46 mmol/l (SD: 0.34); PCr:5.64 mmol/l (SD: 0.83) vs 4.9mmol/l (SD: 1.3) vs 4.95 mmol/l (SD: 0.86); myo-Ins: 4.57 mmol/l (SD:1.05) vs 6.34 mmol/l (SD: 2.03) vs 4.5 mmol/l (SD: 0.96). t-NAA reduction in MS plaques and WML was significant compared with controls (p
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- Adult -
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- Aspartic Acid - analogs and derivatives
- Brain - metabolism
- Case-Control Studies - metabolism
- Creatine - metabolism
- Female - metabolism
- Fourier Analysis - metabolism
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- Inositol - metabolism
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- Magnetic Resonance Spectroscopy - metabolism
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- Find related publications in this database (Keywords)
- multiple sclerosis
- white matter lesions
- magnetic resonance spectroscopy