Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhang, M; Brown, MR; Bentley, AR; Winkler, TW; Noordam, R; Nagarajan, P; Guo, B; Lee, S; Schwander, K; Wang, W; Westerman, K; O'Connell, JR; Ammous, F; Argoty-Pantoja, AD; Bartz, TM; Batini, C; Boua, PR; Cordell, HJ; Díez-Ahijado, L; Dimitrov, L; Do, AN; Du, J; Feitosa, MF; Giri, A; Giulianini, F; Gudmundsdottir, V; Guo, X; Harris, SE; Hasbani, NR; Herold, JM; Hikino, K; Hofer, E; Hsu, FC; Jackson, AU; Kho, M; Kraja, AT; Lyytikäinen, LP; Meirhaeghe, A; Muntaner, M; Nakatochi, M; Nardone, GG; Nutile, T; Palmer, ND; Pecori, A; Rao, VS; Rauramaa, R; Sanghvi, MM; Santin, A; Shen, B; Stringham, HM; Takeuchi, F; Tan, YA; Tang, J; Thériault, S; Trofimova, O; Trompet, S; van, der, Most, PJ; Wang, YX; Wang, Z; Wang, Y; Ware, EB; Weiss, S; Wickremasinghe, AR; Yu, C; Zhu, W; Ansari, MAY; Anugu, P; Banas, B; Barr, RG; Basnet, TB; Boerwinkle, E; Böger, CA; Breyer, M; Broeckel, U; Bryant, L; Cade, B; Camarda, S; Cennamo, P; Checkley, W; Chee, ML; Chen, G; Coley, K; Collins, SD; de, Borst, MH; de, Las, Fuentes, L; Deary, IJ; Dupont, CT; Enzinger, C; Faquih, T; Faul, JD; Silva, LF; Gauthier, V; Gepner, AD; Gorski, M; Grabe, HJ; Graff, M; Gu, CC; He, J; Heikkinen, S; Hidalgo, B; Highland, HM; Hixson, JE; Hood, MM; Hunt, SC; Irvin, MR; Isono, M; Kähönen, M; Kardia, SLR; Karvonen-Gutierrez, CA; Kasturiratne, A; Katsuya, T; Kaufman, JD; Koistinen, HA; Komulainen, P; Krämer, BK; Launer, LJ; Leonard, H; Levy, D; Liu, J; Marques-Vidal, P; Martinez-Perez, A; Matsuda, K; McNeil, JJ; Milaneschi, Y; Miranda, JJ; Morrison, JL; Nalls, M; Ng, MC; Nolte, IM; Norris, JM; Oravilahti, A; Patki, A; Petty, LE; Peyser, PA; Pianigiani, G; Raffield, LM; Raitakari, OT; Ramsay, M; Rice, KM; Ridker, PM; Risch, L; Risch, M; Ruggiero, D; Ruiz-Narvaez, EA; Russ, TC; Sabanayagam, C; Vaitinadin, NS; Schmidt, R; Scott, LJ; Singh, S; Sitlani, CM; Smit, RAJ; Smith, JA; Sun, Q; Tai, ES; Taylor, KD; Tesolin, P; Tham, YC; Tinashe, C; van, Dam, RM; Vaucher, J; Völker, U; Wang, C; Wilson, OD; Wong, TY; Xu, J; Yamamoto, K; Yao, J; Yokota, M; Young, KL; Zimmermann, ME; Amouyel, P; Below, JE; Bergmann, S; Bernabe-Ortiz, A; Bierut, L; Boehnke, M; Bowden, DW; Brandenburg, JT; Chasman, DI; Cheng, CY; Ciullo, M; Concas, MP; Conen, D; Cox, SR; Dauchet, L; de, Silva, HJ; Dörr, M; Edwards, TL; Fox, ER; Franceschini, N; Freedman, BI; Girotto, G; Gudnason, V; Harlow, SD; Heid, IM; Hung, AM; Ichihara, S; Jaquish, CE; John, C; Jonas, JB; Jukema, JW; Kato, N; Keavney, BD; Kelly, TN; Laakso, M; Lacaze, P; Lakka, T; Lee, S; Lehtimäki, T; Liu, CT; Loos, RJF; North, KE; Penninx, B; Province, MA; Psaty, BM; Redline, S; Rosendaal, FR; Rotimi, CN; Rotter, JI; Sabater-Lleal, M; Schmidt, H; Sim, X; Snieder, H; Spedicati, B; Stark, KJ; Terao, C; Wagenknecht, LE; Weir, DR; Zhao, W; Zhu, X; Munroe, PB; Sun, YV; Gauderman, J; Manning, AK; Fornage, M; Aschard, H; Wang, H; de, Vries, PS; Wang, G; Rao, DC; Morrison, AC; Chen, H, , Lifelines, Cohort, Study;Biobank, Japan, Project.
Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.
medRxiv. 2025;
Doi: 10.1101/2025.10.06.25337440
[OPEN ACCESS]
PubMed
FullText
FullText_MUG
- Autor*innen der Med Uni Graz:
- Enzinger Christian
- Hofer Edith
- Schmidt Helena
- Schmidt Reinhold
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cigarette smoking influences blood pressure (BP) levels. Studying and accounting for potential gene-smoking interactions can help discover novel loci and provide insights into biological pathways for smoking-associated BP regulation. We conducted a genome-wide association meta-analysis involving 1,188,241 individuals from 66 studies in five ancestry groups, analyzing systolic BP, diastolic BP, and pulse pressure while considering interactions between genetic variants and three smoking exposures: smoking status, cigarettes per day, and pack years. These analyses identified twelve novel loci for BP at genome-wide significance (