Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Jahn, S; Krajina, K; Smolle, MA; Neufeldt, D; Jonas, K; Rinner, B; Mellert, K; Noeparast, M; Trepel, M; Szkandera, J; Pichler, M; Liegl-Azwanger, B.
Clinical Significance and Therapeutic Potential of Long Non-Coding RNA H19 in Soft Tissue Sarcoma.
Cancer Med. 2026; 15(1):e71305
Doi: 10.1002/cam4.71305
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Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Jahn Stephan
- Liegl-Atzwanger Bernadette
- Pichler Martin
- Co-Autor*innen der Med Uni Graz
- Jonas Katharina
- Rinner Beate
- Smolle Maria Anna
- Szkandera Joanna
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- Abstract:
- BACKGROUND: Long non-coding RNA (lncRNA) H19 plays a pivotal role in the pathogenesis of different human cancers, but its role in soft tissue sarcoma (STS) has not yet been defined. METHODS: We analyzed H19 expression patterns in various cancer cell lines, focusing on sarcoma subtypes. RNA in situ hybridization was performed on a tissue microarray (n = 150) to assess H19 expression in human STS samples. Univariate and multivariate analyses were conducted to evaluate H19's prognostic value. In STS cell lines with high H19 expression, a Gapmer-based knock-down approach was used to study the functional impact of H19 expression. RESULTS: Low H19 expression was associated with poor prognosis in univariate analysis (HR: 0.564; 95% CI: 0.324-0.985; p = 0.044). Multivariate analysis showed advanced patient age (p < 0.001) and large tumor size (p = 0.002) as independent predictors of worse overall survival, irrespective of H19 expression (HR: 0.655; 95% CI: 0.367-1.170; p = 0.153). H19 knockdown in STS cell lines reduced cellular growth and increased pro-apoptotic activity. DISCUSSION: Our findings suggest that H19 might play a role in STS pathogenesis. While its prognostic value requires further investigation, H19-based targeting approaches may warrant evaluation for therapeutic potential in STS.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- RNA, Long Noncoding - genetics
- Male - administration & dosage
- Female - administration & dosage
- Middle Aged - administration & dosage
- Sarcoma - genetics, pathology, mortality, therapy
- Prognosis - administration & dosage
- Cell Line, Tumor - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Gene Expression Regulation, Neoplastic - administration & dosage
- Biomarkers, Tumor - genetics
- Cell Proliferation - administration & dosage
- Apoptosis - genetics
- Gene Knockdown Techniques - administration & dosage
- Young Adult - administration & dosage
- Clinical Relevance - administration & dosage
- Find related publications in this database (Keywords)
- H19
- long non-coding RNA
- soft tissue sarcoma