Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stead, TE; Cvirn, G; De Boever, P; Bergauer, A; Green, DA; White, O; Arron, HE; Blaber, AP; Goswami, N.
Blood coagulability changes in females exposed to dry immersion: examining a mechanism for the development of venous thromboembolism in microgravity
ACTA ASTRONAUT. 2026; 240: 99-105.
Doi: 10.1016/j.actaastro.2025.11.065
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Goswami Nandu
- Co-Autor*innen der Med Uni Graz
- Cvirn Gerhard
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- Abstract:
- The recent report of a blood clot in the internal jugular vein (IJV) of an astronaut aboard the International Space Station (ISS) has prompted the need of the international scientific community to investigate the potential underlying pathophysiology. Current published research on this topic is male-centered, despite known clotting sexdifferences and heightened risk for females on Earth. In this study, we assessed the hemostatic responses of female participants exposed to dry immersion simulated microgravity. Based on previous evidence from studies of males in simulated microgravity (head-down tilt bedrest), we hypothesized an initial increase in procoagulation activity along with increased anticoagulation activity. Eighteen healthy female participants (28.2 +/- 4.1 years, 59.4 +/- 6.4 kg, 64.7 +/- 6.0 cm) took part in the ESA-sponsored VIVALDI I five-day dry immersion study. Coagulation risk was assessed with rotational thromboelastometry and thrombin-antithrombin tests. The results showed a significant increase from baseline for coagulation and maximum clot firmness measurements, and a decrease in clot formation time by the last day of dry immersion. Thrombin-antithrombin levels were unchanged in response to dry immersion. These data present evidence of significant changes in hemostatic responses for females exposed to five days of dry immersion and suggest a possibility for increased clotting risks during flight.
- Find related publications in this database (Keywords)
- Female
- Venous thrombo-embolism
- Thrombin-antithrombin
- Coagulation time
- Clot formation time
- Dry immersion