Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hagelkruys, A; Wirnsberger, G; Stadlmann, J; Wöhner, M; Horrer, M; Vilagos, B; Jonsson, G; Kogler, M; Tortola, L; Novatchkova, M; Bönelt, P; Hoffmann, D; Koglgruber, R; Steffen, U; Schett, G; Busslinger, M; Bergthaler, A; Klein, C; Penninger, JM.
A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans.
J Exp Med. 2021; 218(1):
Doi: 10.1084/jem.20200559
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Jonsson Gustav
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Jagunal homolog 1 (JAGN1) has been identified as a critical regulator of neutrophil biology in mutant mice and rare-disease patients carrying JAGN1 mutations. Here, we report that Jagn1 deficiency results in alterations in the endoplasmic reticulum (ER) of antibody-producing cells as well as decreased antibody production and secretion. Consequently, mice lacking Jagn1 in B cells exhibit reduced serum immunoglobulin (Ig) levels at steady state and fail to mount an efficient humoral immune response upon immunization with specific antigens or when challenged with viral infections. We also demonstrate that Jagn1 deficiency in B cells results in aberrant IgG N-glycosylation leading to enhanced Fc receptor binding. Jagn1 deficiency in particular affects fucosylation of IgG subtypes in mice as well as rare-disease patients with loss-of-function mutations in JAGN1. Moreover, we show that ER stress affects antibody glycosylation. Our data uncover a novel and key role for JAGN1 and ER stress in antibody glycosylation and humoral immunity in mice and humans.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Endoplasmic Reticulum Stress - genetics, immunology
- Glycosylation - administration & dosage
- Humans - administration & dosage
- Immunity, Humoral - administration & dosage
- Immunoglobulin G - genetics, immunology
- Loss of Function Mutation - administration & dosage
- Membrane Proteins - genetics, immunology
- Mice, Knockout - administration & dosage
- Receptors, Fc - genetics, immunology
- Mice - administration & dosage