Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Atallah, R; Gindlhuber, J; Heinemann, A.
Succinate in innate immunity: linking metabolic reprogramming to immune modulation
FRONT IMMUNOL. 2025; 16: 1661948
Doi: 10.3389/fimmu.2025.1661948
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- Führende Autor*innen der Med Uni Graz
- ATALLAH Reham
- Heinemann Akos
- Co-Autor*innen der Med Uni Graz
- Gindlhuber Jürgen
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- Abstract:
- Succinate is an essential metabolite in the tricarboxylic acid (TCA) cycle. In mitochondria, succinate holds a unique position connecting the TCA cycle and the electron transport chain (ETC), thereby providing a shortcut path for adenosine triphosphate (ATP) production. Beyond this fundamental role in cellular metabolism, succinate is increasingly acknowledged as a key modulator of immune cell function. Production of reactive oxygen species (ROS), hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, protein succinylation and cell-cell communication mediated by succinate receptor 1 (SUCNR1) are traits induced by succinate. During inflammation, succinate plays key dual roles, culminating in either pro- or anti-inflammatory effects that are tissue- and context-dependent. In this review, we provide a succinct overview focusing on the regulatory role of succinate in innate immune cells, highlighting involved mechanisms and research gaps that represent promising targets for future study.
- Find related publications in this database (Keywords)
- succinate
- innate immune cells
- succinate dehydrogenase (SDH)
- reactive oxygen species (ROS)
- hypoxia-inducible factor-1 alpha (HIF-1 alpha)
- succinylation
- succinate receptor 1 (SUCNR1)
- inflammation