Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hatzl, S; Posch, F; Schulz, E; Uhl, B; Hodl, I; Forstner, P; Sareban, N; Moritz, M; Dreo, B; Lackner, A; Kleinhappl, B; Moazedi-Fürst, F; Khalil, M; Enzinger, C; Eller, P; Krammer, F; Krause, R; Stradner, MH; Steinmetz, I; Schlenke, P; Fessler, J; Greinix, H.
Altered immune responses to mRNA vaccination against SARS-COV-2 are characterized by an impaired cross-talk between humoral and T-cellular immune compartments in patients with hematologic diseases.
Vaccine. 2025; 63: 127666
Doi: 10.1016/j.vaccine.2025.127666
PubMed
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- Autor*innen der Med Uni Graz:
- Dreo Barbara
- Eller Philipp
- Enzinger Christian
- Fessler Johannes
- Forstner Patrick
- Greinix Hildegard
- Hatzl Stefan
- Hodl Isabel
- Khalil Michael
- Kleinhappl Barbara
- Krause Robert
- Lackner Angelika
- Moazedi-Fürst Florentine
- Moritz Martina
- Posch Florian
- Sareban Nazanin
- Schlenke Peter
- Schulz Eduard
- Steinmetz Ivo
- Stradner Martin Helmut
- Uhl Barbara
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- Abstract:
- BACKGROUND: Patients with hematologic diseases frequently develop insufficient humoral immunity following mRNA vaccination against SARS-COV-2. Data on the T-cellular immune response to SARS-COV-2 mRNA vaccination and its impact on the humoral compartment in this patient population is limited. METHODS: Here, we performed a detailed analysis of T-cellular immune responses 21-28 days after the second dose of mRNA vaccination in hematologic patients suffering from different disease entities using ELISpot assay and flow cytometry. Anti-SARS-CoV-2 spike receptor-binding domain antibody assays were performed to describe humoral B-cell response. To complement our cellular analysis, we quantified T- and B-cell subsets by immunophenotyping. FINDINGS: We show that SARS-CoV-2 mRNA vaccination elicits T-cell responses in patients suffering from hematologic diseases, but the orchestrated process of T-cell activation with a uniform involvement of CD4+ and CD8+ T-cells as seen in healthy controls was highly altered. Moreover, we observed that humoral immune response in hematologic patients was uncorrelated with T-cell effector function and immune cell composition. INTERPRETATION: Our data show disturbed T-cellular immunity and a loss of cross-talk between humoral and T-cellular immune compartments following mRNA vaccination in hematologic patients.