Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nathan, SD; Piccari, L; Abman, SH; Balasubramanian, A; Girgis, RE; Kovacs, G; Olschewski, H; Shlobin, OA; Stockbridge, N; Wort, SJ; Washko, GR; Nikkho, SM.
Significance of Pulmonary Vascular Dysfunction in Chronic Obstructive Pulmonary Disease
PULM CIRC. 2025; 15(3): e70144
Doi: 10.1002/pul2.70144
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- Co-Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Horst
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- Abstract:
- Chronic obstructive pulmonary disease (COPD) is frequently accompanied by abnormalities of the pulmonary vasculature. This vasculopathy spans the spectrum from mild vascular dysfunction to pulmonary hypertension, which on rare occasions can be severe. Given the worldwide prevalence of COPD, it is conceivable that the morbidity and mortality associated with pulmonary vascular dysfunction have been vastly underappreciated, especially in countries and regions where the infrastructure and resources to define the magnitude of the problem are often limited. This article reflects deliberations of the Pulmonary Vascular Research Institute's Innovative Drug Development Initiative (PVRI IDDI) Group 3 Pulmonary Hypertension Workstream on the role of the pulmonary vasculature in COPD. In this introductory paper, we lay the foundation for forthcoming papers by our group, with our ultimate goals being to increase awareness and encourage more research, including clinical trials, to address this unmet need.
- Find related publications in this database (Keywords)
- chronic obstructive pulmonary disease
- clinical trial design and endpoints
- epidemiology
- prognosis
- pulmonary hypertension
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- symptom assessment and management