Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Koestenberger, M; Eber, E; Pichler, G; Sallmon, H.
Pulmonary hypertension associated with bronchopulmonary dysplasia. A multidisciplinary challenge
MONATSSCHR KINDERH. 2025;
Doi: 10.1007/s00112-025-02260-3
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Koestenberger Martin
- Co-Autor*innen der Med Uni Graz
- Eber Ernst
- Pichler Gerhard
- Sallmon Hannes
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- Abstract:
- Bronchopulmonary dysplasia (BPD) is a severe complication of premature birth that can be associated with pulmonary vascular changes and the development of pulmonary hypertension (BPD-PH). Impairment of alveolar diffusion, abnormal vascular remodeling and rarefication of pulmonary vessels (vascular growth cessation) lead to increased pulmonary vascular resistance and right heart failure. Approximately one quarter of all infants with moderate to severe BPD develop BPD-PH, which is associated with a high morbidity and mortality. The ongoing development of PH-specific pharmacotherapy provides new treatment options for infants with BPD-PH. Sildenafil has become the mainstay of modern BPD-PH treatment, while other medications, such as endothelin receptor antagonists and prostacyclin analogues/mimetics are increasingly being investigated; however, pediatric data from randomized controlled trials are currently scarce.
- Find related publications in this database (Keywords)
- Preterm infant
- Interstitial lung disease
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- Preterm infant
- Interstitial lung disease
- Echocardiography
- Endothelin receptor antagonists