Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Melena, I; Piani, F; Tommerdahl, KL; Severn, C; Chung, LT; MacDonald, A; Vinovskis, C; Cherney, D; Pyle, L; Roncal-Jimenez, CA; Lanaspa, MA; Rewers, A; van, Raalte, DH; Cara-Fuentes, G; Parikh, CR; Nelson, RG; Pavkov, ME; Nadeau, KJ; Johnson, RJ; Bjornstad, P.
Aminoaciduria and metabolic dysregulation during diabetic ketoacidosis: Results from the diabetic kidney alarm (DKA) study.
J Diabetes Complications. 2022; 36(6):108203
Doi: 10.1016/j.jdiacomp.2022.108203
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- Autor*innen der Med Uni Graz:
- Piani Federica
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- Abstract:
- OBJECTIVE: We examined changes in the excretion of various amino acids and in glycolysis and ketogenesis-related metabolites, during and after diabetic ketoacidosis (DKA) diagnosis, in youth with known or new onset type 1 diabetes (T1D). METHODS: Urine samples were collected from 40 youth with DKA (52% boys, mean age 11 ± 4 years, venous pH 7.2 ± 0.1, blood glucose 451 ± 163 mg/dL) at 3 time points: 0-8 h and 12-24 h after starting an insulin infusion, and 3 months after hospital discharge. Mixed-effects models evaluated the changes in amino acids and other metabolites in the urine. RESULTS: Concentrations of urine histidine, threonine, tryptophan, and leucine per creatinine were highest at 0-8 h (148.8 ± 23.5, 59.5 ± 12.3, 15.4 ± 1.4, and 24.5 ± 2.4% of urine creatinine, respectively), and significantly decreased over 3 months (p = 0.028, p = 0.027, p = 0.019, and p < 0.0001, respectively). Urine histidine, threonine, tryptophan, and leucine per urine creatinine decreased by 10.6 ± 19.2, 0.7 ± 0.9, 1.3 ± 0.9, and 0.5 ± 0.3-fold, respectively, between 0 and 8 h and 3 months. CONCLUSIONS: In our study, DKA was associated with profound aminoaciduria, suggestive of proximal tubular dysfunction analogous to Fanconi syndrome.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Amino Acids - administration & dosage
- Child - administration & dosage
- Creatinine - administration & dosage
- Diabetes Mellitus, Type 1 - diagnosis
- Diabetic Ketoacidosis - complications
- Diabetic Nephropathies - complications, etiology
- Female - administration & dosage
- Histidine - administration & dosage
- Humans - administration & dosage
- Leucine - administration & dosage
- Male - administration & dosage
- Threonine - administration & dosage
- Tryptophan - administration & dosage