Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Viz-Lasheras, S; Gómez-Carballa, A; Pardo-Seco, J; Bello, X; Rivero-Calle, I; Dacosta, AI; Kaforou, M; Habgood-Coote, D; Cunnington, AJ; Emonts, M; Herberg, JA; Wright, VJ; Carrol, ED; Paulus, SC; Zenz, W; Kohlfürst, DS; van der Flier, M; de Groot, R; Schlapbach, LJ; Agyeman, P; Pollard, AJ; Fink, C; Kuijpers, TT; Anderson, S; Calvo, C; Martínez-Padilla, MD; Pérez-Aragón, A; Gómez-Sánchez, E; Valencia-Ramos, J; Giménez-Sánchez, F; Alonso-Quintela, P; Moreno-Galarraga, L; von Both, U; Pokorn, M; Zavadska, D; Tsolia, M; Vermont, CL; Moll, HA; Levin, M; Martinón-Torres, F; Salas, A; EUCLIDS Consortium; DIAMONDS Consortium; GENDRES Consortium; PERFORM Consortium.
A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia
ISCIENCE. 2025; 28(2): 111747
Doi: 10.1016/j.isci.2025.111747
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- Co-Autor*innen der Med Uni Graz
- Kohlfürst Daniela
- Zenz Werner
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- Abstract:
- Pneumonia stands as the primary cause of death among children under five, yet current diagnosis methods often result in inadequate or unnecessary treatments. Our research seeks to address this gap by identifying host transcriptomic biomarkers in the blood of children with definitive viral and bacterial pneumonia. We performed RNA sequencing on 192 prospectively collected whole blood samples, including 38 controls and 154 pneumonia cases, uncovering a 5-transcript signature (genes FAM20A, BAG3, TDRD9, MXRA7, and KLF14) that effectively distinguishes bacterial from viral pneumonia (area under the curve (AUC): 0.95 [0.88-1.00]). Initial validation using combined definitive and probable cases yielded an AUC of 0.87 [0.77-0.97], while full validation in a new prospective cohort of 32 patients achieved an AUC of 0.92 [0.83-1.00]. This robust signature holds significant potential to enhance diagnostics accuracy for pediatric pneumonia, reducing diagnostic delays and unnecessary treatments and potentially transforming clinical practice.