Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bondarenko, L; Baimuratova, R; Reindl, M; Zach, V; Dzeranov, A; Pankratov, D; Osmushko, I; Kydralieva, K; Dzhardimalieva, G; Kolb, D; Prassl, R; Sterrer, M; Schwaminger, SP.
Designed magnetic nanoparticles for ferroptosis: Release of iron ions from metal-organic frameworks modified with iron oxides
MATER TODAY CHEM. 2024; 42: 102332
Doi: 10.1016/j.mtchem.2024.102332
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- Führende Autor*innen der Med Uni Graz
- Schwaminger Sebastian
- Co-Autor*innen der Med Uni Graz
- Kolb Dagmar
- Prassl Ruth
- Reindl Marco
- Zach Verena
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- Abstract:
- The unique chemical properties of the catalytic and biocompatible metal organic framework MIL88b allow for considering it as prooxidant agent. The authors hypothesize whether additional modification of the MIL88b with an additional iron source as Fe3O4 nanoparticles can increase both pro-oxidant activity and provide magnetic properties contributing to target delivery. The prooxidant activity of the Fe3O4-MOF was studied using electron paramagnetic resonance spectroscopy and methylene blue degradation reactions in the presence of hydrogen peroxide. To understand the reaction mechanism, the authors studied the released iron ions, as well as the surface composition using the X-ray photoelectron spectroscopy method. The addition of iron oxide leads to a more prolonged release of iron ions and the production of hydroxyl radicals within 24 h. The native MIL88b demonstrates the highest Fenton reaction rate due to "sacrificial" behavior (despite lower concentration of iron ions in the composition and on the surface compared to the modified sample) and the blocking of the active centers of MIL88b by Fe3O4 on the surface.
- Find related publications in this database (Keywords)
- Haber-Weiss reaction
- Fenton reaction
- Metal organic framework
- Magnetic iron oxide nanoparticles
- Radical chemistry