Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Leuschner, G; Wenter, V; Milger, K; Zimmermann, GS; Matthes, S; Meinel, FG; Lehner, S; Neurohr, C; Behr, J; Kneidinger, N.
Suspected pulmonary embolism in patients with pulmonary fibrosis: Discordance between ventilation/perfusion SPECT and CT pulmonary angiography.
Respirology. 2016; 21(6):1081-7
Doi: 10.1111/resp.12797
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kneidinger Nikolaus
- Co-Autor*innen der Med Uni Graz
- Milger-Kneidinger Katrin
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- Abstract:
- BACKGROUND AND OBJECTIVE: Pulmonary embolism (PE) is a common differential diagnosis in patients with pulmonary fibrosis presenting with a clinical deterioration. Both ventilation/perfusion (V/Q)-single photon emission computed tomography (SPECT) and computed tomographic pulmonary angiography (CTPA) are routinely used to detect PE. However, the value of V/Q-SPECT and CTPA in this scenario has not been studied so far. We aimed to investigate the concordance of V/Q-SPECT and CTPA in patients with pulmonary fibrosis and suspicion of pulmonary embolism. METHODS: A total of 22 consecutive patients with pulmonary fibrosis and clinical deterioration who underwent both V/Q-SPECT and CTPA were included in the study and analyzed for the presence of pulmonary embolism. RESULTS: Nine of 22 patients (41%) had evidence for pulmonary embolism in V/Q-SPECT, and two of these patients had matching evidence for pulmonary embolism in CTPA. In the other seven patients with positive findings in V/Q-SPECT, no evidence of pulmonary embolism was found in CTPA. None of the 13 patients with a negative V/Q-SPECT had evidence for pulmonary embolism in CTPA. CONCLUSION: In patients with pulmonary fibrosis and suspected pulmonary embolism, pulmonary embolism is detected more frequently by V/Q-SPECT than by CTPA. Thromboembolic disease is identified on CTPA only in a minority of patients with positive findings on V/Q-SPECT. When making treatment decisions, clinicians should be aware of the high rate of discordant findings in V/Q-SPECT and CTPA in this specific patient population.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Comparative Effectiveness Research - administration & dosage
- Computed Tomography Angiography - methods
- Diagnosis, Differential - administration & dosage
- Disease Progression - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lung - diagnostic imaging
- Male - administration & dosage
- Middle Aged - administration & dosage
- Pulmonary Embolism - diagnosis
- Pulmonary Fibrosis - diagnosis, physiopathology
- Reproducibility of Results - administration & dosage
- Tomography, Emission-Computed, Single-Photon - methods
- Find related publications in this database (Keywords)
- lung disease
- multidetector computed tomography
- pulmonary embolism
- pulmonary fibrosis
- radionuclide imaging