Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schiopu, SRI; Zacherl, M; Todica, A; Bartenstein, P; Milger, K; Leuschner, G; Munker, D; Bauer, M; Massberg, S; Behr, J; Neurohr, C; Huber, BC; Kneidinger, N.
Feasibility and accuracy of SPECT myocardial perfusion imaging in end-stage lung disease.
J Nucl Cardiol. 2020; 27(3):903-911
Doi: 10.1007/s12350-019-01851-4
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kneidinger Nikolaus
- Milger-Kneidinger Katrin
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- Abstract:
- BACKGROUND: Coronary artery disease (CAD) is associated with increased mortality in patients with chronic lung disease. However, non-invasive diagnostic of CAD is difficult, especially in patients with more advanced disease. Therefore, we aimed to assess the feasibility and accuracy of SPECT-myocardial perfusion imaging (MPI) stress testing with regadenoson in patients with end-stage lung disease (ELD) undergoing assessment of stable CAD. METHODS: Between January 2012 and May 2018, 102 patients with ELD, who were referred to our institution for lung transplant evaluation, were assessed retrospectively. All patients underwent both stress SPECT-MPI as well as coronary angiography. RESULTS: The mean age in our population was 57±6 years. All patients had severe pulmonary function impairment. During stress SPECT-MPI 14 patients (14%) reported regadenoson-related symptoms, but only 2 patients (2%) required medical treatment. Coronary angiography revealed obstructive CAD in 20 patients (20%). Among those, 5 patients had abnormal SPECT-MPI and PCI was performed in 3 patients accordingly. In 14 patients with obstructive CAD, revascularization was deferred based on normal SPECT-MPI findings. CONCLUSIONS: SPECT-MPI using regadenoson is well tolerated in patients with ELD and can help to make decisions about coronary revascularization before lung transplant.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Coronary Angiography - methods
- Coronary Artery Disease - diagnostic imaging
- Cross-Sectional Studies - administration & dosage
- Feasibility Studies - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Lung Neoplasms - diagnostic imaging
- Male - administration & dosage
- Middle Aged - administration & dosage
- Myocardial Perfusion Imaging - methods
- Percutaneous Coronary Intervention - administration & dosage
- Purines - administration & dosage
- Pyrazoles - administration & dosage
- Reproducibility of Results - administration & dosage
- Retrospective Studies - administration & dosage
- Tomography, Emission-Computed, Single-Photon - methods
- Find related publications in this database (Keywords)
- COPD
- ILD
- stress testing
- coronary artery disease
- myocardial perfusion imaging
- SPECT