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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Munker, D; Veit, T; Schönermarck, U; Arnold, P; Leuschner, G; Barton, J; Mümmler, C; Briegel, I; Mumm, JN; Zoller, M; Kauke, T; Sisic, A; Ghiani, A; Walter, J; Milger, K; Mueller, S; Michel, S; Munker, S; Keppler, OT; Fischereder, M; Meiser, B; Behr, J; Kneidinger, N; Neurohr, C.
Polyomavirus exerts detrimental effects on renal function in patients after lung transplantation.
J Clin Virol. 2021; 145:105029 Doi: 10.1016/j.jcv.2021.105029
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Kneidinger Nikolaus; Milger-Kneidinger Katrin
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Abstract:: INTRODUCTION: Chronic kidney disease (CKD) is associated with significant morbidity and mortality after lung transplantation (LTX). Calcineurin inhibitor (CNI) nephrotoxicity is the leading cause of CKD. After kidney transplantation, polyomavirus-associated nephropathy (PyVAN) is a well-recognized problem. This study aims to evaluate the role of polyomavirus in patients after LTX. METHODS: From January 2017 to January 2020, all lung transplant recipients who performed follow-up visits in our center were included in the study and retrospectively assessed. We measured renal function (creatinine levels before and after transplantation), JCPyV, and BKPyV load by polymerase chain reaction (PCR) in serum and urine samples after transplantation. RESULTS: In total, 104 consecutive patients (59 males, 56.7%) with a mean age of 49.6 ± 11.1 years were identified. JCPyV was found in urine of 36 patients (34.6%) and serum of 3 patients (2.9%). BKPyV was found in urine of 40 patients (38.5%) and serum of 4 patients (3.8%), respectively. Urine evidence for JCPyV (p < 0.001, coefficient: +21.44) and BKPyV (p < 0.001, coefficient: +29.65) correlated highly with further kidney function decline. CONCLUSION: Kidney function deterioration is associated with JCPyV and BKPyV viruria in patients after LTX. This might indicate a role of PyVAN in lung transplant recipients.
Find related publications in this database (using NLM MeSH Indexing): Adult - administration & dosage; BK Virus - administration & dosage; Female - administration & dosage; Humans - administration & dosage; Kidney - physiopathology; Lung Transplantation - adverse effects; Male - administration & dosage; Middle Aged - administration & dosage; Polyomavirus - administration & dosage; Polyomavirus Infections - complications; Retrospective Studies - administration & dosage; Tumor Virus Infections - complications
Find related publications in this database (Keywords): Lung transplantation; LTX; BK Virus; JC Virus; Polyomavirus associated nephropathy; BK nephropathy; PyVAN; JCPyV; BKPyV