Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Funk, GC; Doberer, D; Fuhrmann, V; Holzinger, U; Kitzberger, R; Kneidinger, N; Lindner, G; Schneeweiss, B.
The acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in non-paracetamol-induced acute liver failure
J HEPATOL. 2006; 45(3): 387-392.
Doi: 10.1016/j.jhep.2006.03.011
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Kneidinger Nikolaus
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- Abstract:
- Background/Aims: Hyperlactatemia with unexplained absence of metabolic acidosis is observed in acute liver failure. In chronic liver disease offsetting metabolic acid-base disorders could be revealed by means of physical-chemical acid-base analysis. The purpose of this study was to determine whether the acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in acute liver failure. Methods: Serial arterial blood samples of 46 consecutive patients with non-paracetamol-induced acute liver failure were studied after admission to a medical ICU in a prospective investigation and compared to healthy controls. Acid-base state was assessed by quantitative physical-chemical analysis. Results: Lactate was increased and albumin was decreased in patients with acute liver failure compared to healthy controls resulting in normal net metabolic acid-base state. The alkalinizing effect of hypoalbuminemia was neutralized by the acidifying effect of elevated lactate. This observation was confirmed in serial analysis during 5 days after admission. Conclusions: The acidifying effect of lactate is neutralized by the alkalinizing effect of hypoalbuminemia in non-paracetamol-induced acute liver failure. The absence of apparent metabolic acidosis in the presence of elevated lactate can be explained by means of the physical-chemical acid-base model. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- lactate
- acid-base state
- liver failure