Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Schnedl, WJ; Michaelis, S; Mangge, H; Enko, D.
One sip of water with LT-4 supplementation-a key to euthyroidism in Hashimoto's thyroiditis.
Endocrine. 2024; 86(1):233-238
Doi: 10.1007/s12020-024-03829-w
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- Führende Autor*innen der Med Uni Graz
- Schnedl Wolfgang
- Co-Autor*innen der Med Uni Graz
- Enko Dietmar
- Mangge Harald
- Michaelis Simon
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- Abstract:
- PURPOSE: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication. PATIENTS AND METHODS: We report on 35 HT patients with LT-4 therapy in this retrospective evaluation. In general, we recommend that a maximum of two sips of water, which would then amount to < 50 mL, be ingested at the same time as LT-4. We report on follow up examinations measuring TSH and antibodies against thyroid peroxidase (TPOAb) after 6 months to five years. RESULTS: After median time of 643 days (range 98-1825) we found in 35 HT patients a statistical significant reduction of serum TSH (p < 0.001) and TPOAb (p = 0.006). The patients median body weight was 71 kg (range 48-98) and a daily LT-4 dosage was used with median 69.1 µg (range 25-150). This results in a daily LT-4 dose of median 1.01 µg/kg bodyweight (range 0.3-2.3). CONCLUSIONS: The reduction of water ingestion to a maximum of two sips, which is <50 mL, combined with LT-4 supplementation helps to achieve euthyroidism in HT. In addition, it reduces the L-T4 medication dosage needed to lower TSH serum levels and decreases TPO antibodies in HT.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Hashimoto Disease - drug therapy, blood
- Thyroxine - administration & dosage, therapeutic use, blood
- Female - administration & dosage
- Middle Aged - administration & dosage
- Thyrotropin - blood
- Retrospective Studies - administration & dosage
- Male - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Iodide Peroxidase - immunology
- Autoantibodies - blood
- Water - administration & dosage
- Find related publications in this database (Keywords)
- Hashimoto's thyroiditis
- Hypothyroidism
- Thyroid peroxidase
- Levothyroxine
- Thyrotropin