Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ou, AH; Rosenthal, SB; Adli, M; Akiyama, K; Akula, N; Alda, M; Amare, AT; Ardau, R; Arias, B; Aubry, JM; Backlund, L; Bauer, M; Baune, BT; Bellivier, F; Benabarre, A; Bengesser, S; Bhattacharjee, AK; Biernacka, JM; Cervantes, P; Chen, GB; Chen, HC; Chillotti, C; Cichon, S; Clark, SR; Colom, F; Cousins, DA; Cruceanu, C; Czerski, PM; Dantas, CR; Dayer, A; Del, Zompo, M; Degenhardt, F; DePaulo, JR; Étain, B; Falkai, P; Fellendorf, FT; Ferensztajn-Rochowiak, E; Forstner, AJ; Frisén, L; Frye, MA; Fullerton, JM; Gard, S; Garnham, JS; Goes, FS; Grigoroiu-Serbanescu, M; Grof, P; Gruber, O; Hashimoto, R; Hauser, J; Heilbronner, U; Herms, S; Hoffmann, P; Hofmann, A; Hou, L; Jamain, S; Jiménez, E; Kahn, JP; Kassem, L; Kato, T; Kittel-Schneider, S; König, B; Kuo, PH; Kusumi, I; Lackner, N; Laje, G; Landén, M; Lavebratt, C; Leboyer, M; Leckband, SG; Jaramillo, CAL; MacQueen, G; Maj, M; Manchia, M; Marie-Claire, C; Martinsson, L; Mattheisen, M; McCarthy, MJ; McElroy, SL; McMahon, FJ; Mitchell, PB; Mitjans, M; Mondimore, FM; Monteleone, P; Nievergelt, CM; Nöthen, MM; Novák, T; Ösby, U; Ozaki, N; Papiol, S; Perlis, RH; Pisanu, C; Potash, JB; Pfennig, A; Reich-Erkelenz, D; Reif, A; Reininghaus, EZ; Rietschel, M; Rouleau, GA; Rybakowski, JK; Schalling, M; Schofield, PR; Schubert, KO; Schulze, TG; Schweizer, BW; Seemüller, F; Severino, G; Shekhtman, T; Shilling, PD; Shimoda, K; Simhandl, C; Slaney, CM; Squassina, A; Stamm, T; Stopkova, P; Tighe, SK; Tortorella, A; Turecki, G; Vieta, E; Volkert, J; Witt, S; Wray, NR; Wright, A; Young, LT; Zandi, PP; Kelsoe, JR.
Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study.
Transl Psychiatry. 2024; 14(1): 109
Doi: 10.1038/s41398-024-02811-4
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Bengesser Susanne
- Dalkner Nina
- Fellendorf Frederike
- Reininghaus Eva
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Lithium - pharmacology, therapeutic use
- Bipolar Disorder - drug therapy, genetics
- Proto-Oncogene Proteins c-akt - genetics
- Phosphatidylinositol 3-Kinases - genetics
- Genome-Wide Association Study - administration & dosage
- Multiomics - administration & dosage
- Focal Adhesions - administration & dosage