Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ratiu, IA; Bocos-Bintintan, V; Monedeiro, F; Milanowski, M; Ligor, T; Buszewski, B.
An Optimistic Vision of Future: Diagnosis of Bacterial Infections by Sensing Their Associated Volatile Organic Compounds.
Crit Rev Anal Chem. 2020; 50(6): 501-512.
Doi: 10.1080/10408347.2019.1663147
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Monedeiro-Milanowski Maciej
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- Abstract:
- Simple tests using sniff analysis that have the ability of diagnosing and rapidly distinguishing between infections due to different bacteria are urgently required by medical community worldwide. Professionals interested in this topic wish for these tests to be simultaneously cheap, fast, easily applicable, non-invasive, robust, reliable, and sensitive. Current analytical instrumentation has already the ability for performing real time (minutes or a few dozens of minutes) analysis of volatile bacterial biomarkers (the VOCs emitted by bacteria). Although many articles are available, a review displaying an objective evaluation of the current status in the field is still needed. This review tries to present an overview regarding the bacterial biomarkers released from in vitro cultivation of various bacterial strains and also from different biological matrices investigated, over the last 10 years. We have described results of relevant studies, which used modern analytical techniques to evaluate specific biomarker profiles associated with bacterial infections. Our purpose was to present a comprehensive view of available possibilities for detection of emitted bacterial VOCs from different matrices. We intend that this review to be of general interest for both medical doctors and for all researchers preoccupied with bacterial infectious diseases and their rapid diagnosis using analytical instrumentation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Bacteria - metabolism
- Bacterial Infections - diagnosis, urine
- Biomarkers - metabolism, urine
- Feces - chemistry, microbiology
- Humans - administration & dosage
- Volatile Organic Compounds - metabolism, urine
- Find related publications in this database (Keywords)
- Analytical instrumentation
- bacterial biomarkers
- bacterial infection
- diagnostic tool
- trace detection of VOCs