Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stadler, JT; Habisch, H; Prüller, F; Mangge, H; Bärnthaler, T; Kargl, J; Pammer, A; Holzer, M; Meissl, S; Rani, A; Madl, T; Marsche, G.
HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function.
Antioxidants (Basel). 2023; 12(11):
Doi: 10.3390/antiox12112009
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Marsche Gunther
- Stadler Julia
- Co-Autor*innen der Med Uni Graz
- Bärnthaler Thomas
- Habisch Hansjörg
- Holzer Michael
- Kargl Julia
- Madl Tobias
- Meissl Sabine
- Pammer Anja
- Prüller Florian
- RANI Alankrita
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- COVID-19, caused by the SARS-CoV-2 coronavirus, emerged as a global pandemic in late 2019, resulting in significant global public health challenges. The emerging evidence suggests that diminished high-density lipoprotein (HDL) cholesterol levels are associated with the severity of COVID-19, beyond inflammation and oxidative stress. Here, we used nuclear magnetic resonance spectroscopy to compare the lipoprotein and metabolic profiles of COVID-19-infected patients with non-COVID-19 pneumonia. We compared the control group and the COVID-19 group using inflammatory markers to ensure that the differences in lipoprotein levels were due to COVID-19 infection. Our analyses revealed supramolecular phospholipid composite (SPC), phenylalanine, and HDL-related parameters as key discriminators between COVID-19-positive and non-COVID-19 pneumonia patients. More specifically, the levels of HDL parameters, including apolipoprotein A-I (ApoA-I), ApoA-II, HDL cholesterol, and HDL phospholipids, were significantly different. These findings underscore the potential impact of HDL-related factors in patients with COVID-19. Significantly, among the HDL-related metrics, the cholesterol efflux capacity (CEC) displayed the strongest negative association with COVID-19 mortality. CEC is a measure of how well HDL removes cholesterol from cells, which may affect the way SARS-CoV-2 enters cells. In summary, this study validates previously established markers of COVID-19 infection and further highlights the potential significance of HDL functionality in the context of COVID-19 mortality.
- Find related publications in this database (Keywords)
- COVID-19
- HDL
- NMR metabolomics
- lipoprotein profiling
- cholesterol efflux capacity