Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schreiber, N; Reisinger, AC; Hatzl, S; Schneider, N; Scholz, L; Herrmann, M; Kolland, M; Schuller, M; Kirsch, AH; Eller, K; Kink, C; Fandler-Höfler, S; Rosenkranz, AR; Hackl, G; Eller, P.
Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients.
iScience. 2023; 26(10): 108044
Doi: 10.1016/j.isci.2023.108044
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- Führende Autor*innen der Med Uni Graz
- Eller Philipp
- Schreiber Nikolaus
- Co-Autor*innen der Med Uni Graz
- Eller Kathrin
- Fandler-Höfler Simon
- Hackl Gerald
- Hatzl Stefan
- Herrmann Markus
- Kirsch Alexander
- Kolland Michael
- Reisinger Alexander Christian
- Rosenkranz Alexander
- Schneider Nikolaus
- Scholz Laura
- Schuller Max
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- Abstract:
- Carbohydrate-deficient transferrin (CDT) and the γ-glutamyltransferase-CDT derived Anttila-Index are established biomarkers for sustained heavy alcohol consumption and their potential role to predict delirium and mortality in critically ill patients is not clear. In our prospective observational study, we included 343 consecutive patients admitted to our ICU, assessed the occurrence of delirium and investigated its association with biomarkers of alcohol abuse measured on the day of ICU admission. 35% of patients developed delirium during ICU stay. We found significantly higher CDT levels (p = 0.011) and Anttila-Index (p = 0.001) in patients with delirium. CDT above 1.7% (OR 2.06), CDT per percent increase (OR 1.26, AUROC 0.75), and Anttila-Index per unit increase (OR 1.28, AUROC 0.74) were associated with delirium development in adjusted regression models. Anttila-Index and CDT also correlated with delirium duration exceeding 5 days. Additionally, Anttila-Index above 4, Anttila-Index per unit increase, and CDT per percent increase were independently associated with hospital mortality.