Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hassler, EM; Almer, G; Reishofer, G; Deutschmann, H; Mangge, H; Herrmann, M; Leber, SL; Gunzer, F; Langsenlehner, T; Renner, W.
A sex-specific association of leukocyte telomere length with thigh muscle mass.
Clin Chem Lab Med. 2024; 62(1):150-156
Doi: 10.1515/cclm-2023-0211
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Hassler Eva Maria
- Renner Wilfried
- Co-Autor*innen der Med Uni Graz
- Almer Gunter
- Deutschmann Hannes
- Gunzer Felix
- Herrmann Markus
- Langsenlehner Tanja
- Leber Stefan
- Mangge Harald
- Reishofer Gernot
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- Abstract:
- OBJECTIVES: Telomeres are DNA-protein complexes at the ends of linear chromosomes that protect against DNA degradation. Telomeres shorten during normal cell divisions and therefore, telomere length is an indicator of mitotic-cell age. In humans, telomere shortening is a potential biomarker for disease risk, progression and premature death. Physical activity has been associated with longer leukocyte telomere length (LTL) in some studies. In the current study the relationship between LTL, thigh muscle mass and adipose tissue distribution was explored. METHODS: We performed anthropometric measurements and magnetic resonance imaging (MRI) measurements of the thigh in 149 healthy subjects (77 male, 72 female). LTL was measured using qPCR. Additionally, the subjects answered a questionnaire concerning their training behaviour. RESULTS: In male subjects, LTL was significantly associated with thigh muscle mass, independent of age and body mass index (p=0.006). In addition, a slight association of LTL with weekly endurance units in the male group was found. These relations could not be observed in females. CONCLUSIONS: In conclusion, we observed a sex-specific association of LTL and thigh muscle mass in healthy males. The reason of this sex-specific association is currently unclear, but could be related to different training effects and/or hormonal pathways in men and women.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans - administration & dosage
- Male - administration & dosage
- Female - administration & dosage
- Thigh - administration & dosage
- Telomere - genetics
- Leukocytes - administration & dosage
- Muscles - administration & dosage
- DNA - metabolism
- Find related publications in this database (Keywords)
- leukocyte telomere length
- lean mass
- muscle mass
- magnetic resonance imaging