Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Driva, TS; Schatz, C; Haybaeck, J.
Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis.
Biomolecules. 2023; 13(8):
Doi: 10.3390/biom13081253
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- Ovarian clear cell (OCCC) and endometrioid (EnOC) carcinomas are often subsumed under the umbrella term "endometriosis-associated ovarian cancer" (EAOC), since they frequently arise from ectopic endometrium settled in the ovaries. The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is known to be aberrantly activated both in endometriosis and EAOC; however, its role in the progression of endometriosis to ovarian cancer remains unclear. In fact, cancer-associated alterations in the mTOR pathway may be found in normal uterine epithelium, likely acting as a first step towards ovarian cancer, through the intermediary stage of endometriosis. This review aims to summarize the current knowledge regarding mTOR signaling dysregulation in the uterine endometrium, endometriosis, and EAOC while focusing on the interconnections between the PI3K/AKT/mTOR pathway and other signaling molecules that give rise to synergistic molecular mechanisms triggering ovarian cancer development in the presence of endometriosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Humans - administration & dosage
- Proto-Oncogene Proteins c-akt - administration & dosage
- Phosphatidylinositol 3-Kinases - administration & dosage
- Endometriosis - administration & dosage
- Ovarian Neoplasms - administration & dosage
- TOR Serine-Threonine Kinases - administration & dosage
- Phosphatidylinositol 3-Kinase - administration & dosage
- Carcinoma - administration & dosage
- Find related publications in this database (Keywords)
- endometrium
- endometriosis
- ovarian cancer
- PI3K/AKT/mTOR pathway
- ARID1A mutations