Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rohrer, U; Manninger, M; Fiedler, L; Steinwender, C; Binder, RK; Stühlinger, M; Zirngast, B; Zweiker, D; Zirlik, A; Scherr, D, , Austrian, WCD, Study, Group.
Prevention of Early Sudden Cardiac Death after Myocardial Infarction Using the Wearable Cardioverter Defibrillator-Results from a Real-World Cohort.
J Clin Med. 2023; 12(15):
Doi: 10.3390/jcm12155029
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- Führende Autor*innen der Med Uni Graz
- Rohrer Ursula
- Co-Autor*innen der Med Uni Graz
- Manninger-Wünscher Martin
- Scherr Daniel
- Zirlik Andreas
- Zirngast Birgit
- Zweiker David
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- Abstract:
- BACKGROUND: After acute myocardial infarction (AMI), patients are at risk of sudden cardiac death. The VEST trial failed to show a reduction in arrhythmic mortality in AMI patients with an LVEF ≤ 35% prescribed with a WCD, having a lower-than-expected WCD wearing compliance. OBJECTIVES: The aim was to investigate on outcomes of patients in a real-world Austrian cohort with good compliance. METHODS: A retrospective analysis of all eligible Austrian WCD patients according to the VEST trial inclusion and exclusion criteria between 2010 and 2020 was performed. RESULTS: In total, 105 Austrian patients (64 ± 11 years, 12% female; LVEF 28 ± 6%) received a WCD for a median of 69 (1; 277) days after AMI (wearing duration 23.5 (0; 24) hours/day). Within the first 90 days, 4/105 (3.8%) patients received 9 appropriate shocks (2 (1; 5) shocks). No inappropriate shocks were delivered, and 3/105 (2.9%) patients died during follow-up. Arrhythmic mortality (1.9% Austria vs. 1.6% VEST, p = 0.52), as well as all-cause mortality (2.9% vs. 3.1%, p = 0.42) was comparable in both cohorts. CONCLUSIONS: The WCD is a safe treatment option in a highly selected cohort of patients with LVEF ≤ 35% after AMI. However, despite excellent WCD wearing duration in our cohort, the arrhythmic mortality rate was not significantly different.
- Find related publications in this database (Keywords)
- sudden cardiac death
- implantable cardioverter defibrillator
- wearable cardioverter defibrillator
- acute myocardial infarction
- ventricular fibrillation
- ventricular tachycardia