Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zhou, Z; Li, C; Wang, Z; Haybaeck, J; Zhang, C.
Cd44v6 acts as a directional responding factor in the process of transcoelomic metastasis from gastric carcinoma to Krukenberg tumor.
Expert Rev Mol Diagn. 2023; 23(7):583-588
Doi: 10.1080/14737159.2023.2223981
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Haybäck Johannes
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- Abstract:
- INTRODUCTION: Due to the limited number of studies focusing on the optimal treatment of multiple Krukenberg tumor (KT)-gastric carcinoma (KT - GC), it is necessary to conduct large-scale studies to confirm the definite role of serum tumor markers in the diagnosis and prognosis of KT. Moreover, the clinical significance of variant 6 of CD44 (CD44v6) in transcoelomic metastasis should be considered. AREAS COVERED: This review covers molecular pre-cancer diagnosis, gastric carcinoma metastasis, and anti-cancer treatments. Additionally, gastrointestinal cancer metastasis is a key area for improvement. EXPERT OPINION: The detection of CD44v6 differs in the World Health Organization Classification of Gastric Adenocarcinoma, the Lauren Classification of Gastric Adenocarcinoma, and the anatomic location of gastric adenocarcinoma. The results were compared among the three groups. The mechanism of gastric adenocarcinoma metastasis still requires further elucidation. CD44v6 molecular detection helps clarify the pre-cancer diagnosis of KT before seeding. If subsequent studies confirm its role as a signaling molecule, it could pave the way for new research directions in clinical practice; however, additional academic confirmation is necessary.
- Find related publications in this database (using NLM MeSH Indexing)
- Female - administration & dosage
- Humans - administration & dosage
- Krukenberg Tumor - diagnosis, genetics
- Stomach Neoplasms - diagnosis, genetics
- Adenocarcinoma - diagnosis, genetics
- Biomarkers, Tumor - administration & dosage
- Carcinoma - administration & dosage
- Ovarian Neoplasms - administration & dosage
- Find related publications in this database (Keywords)
- Cd44v6
- Gastric adenocarcinoma
- HA
- Krukenberg tumor
- Molecular diagnosis
- Transcoelomic metastasis
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